Autoimmunity

Step 7 of 7. The T-cell receptor on the T-cell surface can recognise many thousands of different peptides.

Each T-cell receptor can recognise multiple peptides

Autoimmunity is believed to occur when a T-cell that is selected and raised to fight infection then inadvertently recognises a peptide derived from a ‘self’ protein. The net result is that these T-cells then turn on our own tissues.

All autoimmune diseases are genetically linked to certain MHC molecules. MHC molecules are designed to present peptides to T-cells. We therefore believe that rogue T-cells are the root cause of all autoimmunity.

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Beginners Guide to T-cells