Professor Andy Sewell - Publications

Recent High Impact Publications

Cole, D.K., A.M. Bulek, G. Dolton, A.A.J. Schauenberg B. Szomolay, W. Rittase, A. Trimby, P. Jothikumar, Anna Fuller, A. Skowera, J. Rossjohn, C. Zhu, J.J. Miles, M. Peakman, L. Wooldridge, P.J. Rizkallah and A.K. Sewell (2016) Hotspot autoimmune T-cell receptor binding to pathogen and insulin peptides. Journal of Clinical Investigation doi: 10.1172/JCI85679. [Epub ahead of print].

This paper features on the journal cover (June 2016 issue) and is subject of feature article “A ‘hotspot’ for autoimmune T cells in type 1 diabetes” http://dx.doi.org/10.1172/JCI88165. Download

Read commentary:

Stepanek O, Prabhakar AS, Osswald C, King CG, Bulek A, Naeher D, Beaufils-Hugo M, Abanto M, Galati V, Hausmann B, Lang R, Cole DK, Huseb E, Sewell AK, Chakraborty AK, and Palmer E. (2014) Coreceptor-mediated Lck delivery to the TCR sets the antigen dwell-time threshold for central tolerance. Cell. Oct 9;159(2):333-45. doi: 10.1016/j.cell.2014.08.042. Epub 2014 Oct 2. Download

Cell, 159, 333-45 (IMPACT FACTOR 33.1)

Download Nature News and Views

Complete List (reverse chronology)

2007-Present: Professor of Immunology, Cardiff University

173. MacLachlan, B., A. Greenshields-Watson, A.J. Schauenburg, G. Mason, V. Bianchi, A. Fuller, P.J. Rizkallah, A.K. Sewell and D.K. Cole (2017) Using X-ray crystallography, biophysics and functional assays to determine the mechanisms governing T cell receptor recognition of cancer antigens. Journal of Visualized Experiments doi: 10.3791/54991. Download

172. Cole. D.K., H.A. van den Berg, A.Lloyd, M.D. Crowther, K. Beck, J. Ekeruche-Makinde, J.J. Miles, A. M. Bulek, G. Dolton, A.J. Schauenburg, A. Wall, A. Fuller, M. Clement, B. Laugel, P.J. Rizkallah L. Wooldridge and A.K. Sewell (2017) Structural mechanism underpinning peptide cross-reactivity of a human telomerase reverse transcriptase reactive CD8+ T-cell clone. Journal of Biological Chemistry, 292, 802-813. Download

171. Attaf, M. and A.K. Sewell (2016) Disease aetiology and diagnosis by TCR repertoire analysis goes viral (2016) European Journal of Immunology, 46, 2516-19. Download

170. Tsai, M.H., M. Muenchhoff, E. Adland, A. Carlqvist, J. Rolder, D.K. Cole, A.K. Sewell, J. Carson, T. Ndung’u and P.J. Goulder (2016) Paediatric non-progression following grandmother-to-child HIV transmission. Retrovirology 13(1):65. doi: 10.1186/s12977-016-0300-y. Download

169. Pageon S.V., T. Tabarin , Y. Yamamoto , Y. Ma , J.S. Bridgeman , A. Cohnen , C. Benzing , Y. Gao , M. Crowther , K. Tungatt , G. Dolton , A.K. Sewell, D.A Price , O. Acuto , R.G. Parton , J. J. Gooding, J. Rossy , J. Rossjohn and K. Gaus (2016) Functional role of T cell receptor nanoclusters in signal initiation and antigen discrimination. Proceedings of the National Academy of Sciences USA, 113, E5454-63. doi: 10.1073/pnas.1607436113. Download

168. Hanson, W.M., Z. Chen, L.K. Jackson, M. Attaf, A.K. Sewell, J.M. Heemstra and J.D. Phillips (2016) Reversible oligonucleotide chain blocking enables bead capture and amplification of T-cell receptor a and b chain mRNAs. Journal of the American Chemical Society, 138, 11073-6. This article received the journal cover and was featured as a “Spotlight”. It was also featured at the “Research Highlight” in the October 2016 issue of Nature Methods 13:816. Download

167. Meermeier E.W, B.F. Laugel, A.K. Sewell, A.J. Corbett, J. Rossjohn, J. McCluskey, M.J. Harriff T. Franks, M.C. Gold, D.M. Lewinsohn (2016) Human TRAV1-2 negative MR1 restricted T cells allow for broader pathogen recognition. Nature Communications, 16, 12506. doi: 10.1038/ncomms12506. Download

166. Stadinski, B.D., K. Shekhar, I. Gómez-Touriño, J. Jung, K. Sasaki and A.K. Sewell, M. Peakman, A.K. Chakraborty and E.S. Huseby (2016) Hydrophobic CDR3 residues promote the development of self-reactive T cells. Nature Immunology, 17(8), 946-55. Recommended by Faculty of 1000. Download

165. Tan, M.P., G. M. Dolton, A.B. Gerry, J.E. Brewer, A.D. Bennett, N. Pumphrey, B.K. Jakobsen and A. K. Sewell (2016) HLA class I-redirected anti-tumour CD4+ T-cells require a higher TCR binding affinity for optimal activity than CD8+ T-cells. Clinical and Experimental Immunology, 187, 124-137. Download

164. Laugel, B., A. Lloyd, E.W. Meermeier, M.D. Crowther, T.R. Connor, G. Dolton, J.J. Miles, S.R. Burrows, M.C. Gold, D.M. Lewinsohn and A.K. Sewell (2016). Engineering of isogenic cells deficient for MR1 with a CRISPR/Cas9 lentiviral system: tools to study microbial antigen processing and presentation to human MR1-restricted T cells. Journal of Immunology, 197, 971-82. Download

163. Cole, D.K., A.M. Bulek, G. Dolton, A.A.J. Schauenberg B. Szomolay, W. Rittase, A. Trimby, P. Jothikumar, Anna Fuller, A. Skowera, J. Rossjohn, C. Zhu, J.J. Miles, M. Peakman, L. Wooldridge, P.J. Rizkallah and A.K. Sewell (2016) Hotspot autoimmune T-cell receptor binding to pathogen and insulin peptides. Journal of Clinical Investigation, 126, 2191-204. This paper features on the journal cover (June 2016 issue) and is subject of feature article “A ‘hotspot’ for autoimmune T cells in type 1 diabetes” http://dx.doi.org/10.1172/JCI88165. Download

162. Szomolay, B., J. Liu, P.E. Brown, J.J. Miles, M. Clement, S. Llewellyn-Lacey, G. Dolton, J. Ekeruche-Makinde, A. Lissina, A.J. Schauenburg, A.K. Sewell, S.R. Burrows, M. Roederer, D.A. Price, L. Wooldridge and H.A. van den Berg (2016) Identification of human viral protein-derived ligands recognized by individual major histocompatibility complex class I (MHCI)-restricted T-cell receptors Immunology and Cell Biology, 94, 573-82. Download

161. Bianchi, V., A. Bulek, A. Fuller, A. Lloyd, P.J. Rizkallah, G. Dolton, D.K. Cole¶ and A.K. Sewell¶ (2016) A molecular switch abrogates gp100 TCR-targeting of a human melanoma antigen. Journal of Biological Chemistry, 291, 8951-9. (¶Equal contribution). Download

160. Theaker, S.M., C. Rius, A. Greenshields-Watson, A. Lloyd, A. Trimby, A. Fuller, J.J. Miles, D.K. Cole, M. Peakman, G Dolton¶ and A.K. Sewell¶ (2016) T-cell libraries allow simple parallel generation of multiple peptide-specific human T-cell clones. Journal of Immunological Methods, 430, 43-50 (¶Equal contribution). Download

159. Caucheteux, S., J.P. Mitchell, M.O. Ivory, S. Hirosue, S. Hakobyan, G .Dolton, K. Ladell, D.A. Price, A.K. Sewell, F. Nestle, A. Moris, R.O. Karoo, J.C. Birchall, J.A. Hubble, F.P. Blanchet and V. Piguet (2016) Poly(propylene sulfide) nanoparticle p24 vaccine promotes Dendritic Cell mediated specific immune responses against HIV-1. Journal of Investigative Dermatology, 136, 1172-81. Download

158. Holland, C.J., G. Dolton, M. Scurr, K. Ladell, A.J. Schauenburg, K. Miners, F. Madura, A.K. Sewell, D.A. Price, Cole, D.K. and A.J. Godkin (2015) Enhanced detection of antigen-specific CD4+ T cells using altered peptide flanking residue peptide-MHC class II multimers. Journal of Immunology, 195, 5827-36. Download

157. Peakman, M. and A.K. Sewell (2015) Reverse polarity provides shock value in T cell recognition of self. Nature Immunology, 16, 1105-7. Download

156. Dolton, G., K. Tungatt, A. Lloyd, V. Bianchi, S.M. Theaker, A. Trimby, C. Holland, A. Skowera, M. Donia, A.J. Godkin, D.K. Cole, P.T. Straten, M. Peakman, I.M. Svane and A. K. Sewell (2015) More Tricks with Tetramers: A Practical Guide to Staining T cells with peptide-MHC Multimers. Immunology, 146, 11-22. Download

155. Motozono, C., J.A. Pearson, E.D Leenheer, P.J. Rizkallah, K. Beck, A. Trimby, F.S. Wong¶, D.K. Cole¶ and A.K. Sewell¶ (2015) Distortion of the MHC class I binding groove to accommodate an insulin-derived 10-mer peptide. Journal of Biological Chemistry, 290, 18924-33 (¶Equal contribution). This article received the journal cover. Download

154. Gilham, D.E., J. Anderson, J.S. Bridgeman, R.E. Hawkins, M.A. Exley, H.J. Stuass, J. Maher, M. Pule, A.K. Sewell, G. Bendle, S.P. Lee, E.C. Morris (2015) Adoptive T cell therapy for cancer in the UK: A review of activity for the British Society of Gene and Cell Therapy Annual Meeting 2015 (2015) Human Gene Therapy, 26, 276-85. Download

153. Attaf, M., M. Legut, D.K. Cole and A.K. Sewell (2015) The T cell Antigen Receptor: the Swiss Army Knife of the Immune System. Clinical and Experimental Immunology, 181, 1-18. This article was highlighted and received the journal cover. Download

152. Legut, M. D.K. Cole and A.K. Sewell (2015) The Promise of γδ T cells and the γδ T cell Receptor for Cancer Immunotherapy. Cellular and Molecular Immunology (in press) EPub ahead of print doi: 10.1038/cmi.2015.28. Download

151. Motozono, C., J. Bridgeman, D.A. Price, A.K. Sewell and U. Takamasa (2015) Clonotypically similar hybrid αβ TCRs can exhibit markedly different surface expression, antigen specificity and crossreactivity. Clinical and Experimental Immunology, 180, 560-70. Download

150. Neller, M.A., K. Ladell, J.E. McLaren, K.K. Matthews, E. Gostick, J.M. Pentier, G. Dolton, A.J.A. Schauenburg, D. Koning, A. Lsabel, C.A. Fontaine Costa, V. Venturi, C. Smith, R. Khanna, K. Minors, M. Clement, L. Wooldridge, D.K. Cole, D. van Baarle, A.K. Sewell, S.R. Burrows, D.A. Price and J.J. Miles (2015) Naïve CD8+ T cell precursors specific for viral and self-derived targets display structured TCR repertoires and composite antigen-driven dynamics. Immunology and Cell Biology, 93, 625-33. Download

149. Attaf, M., E. Huseby and A.K. Sewell (2015) αβ T-cell receptors as predictors of health and disease. Cellular and Molecular Immunology, 12, 391-9. Download

148. Kloverpris, H., D.K. Cole, A. Fuller, J. Carlson, K. Beck, A.A.J Schauenburg, P.J. Rizkallah, S. Buus, Phillip Goulder¶ and A.K. Sewell¶ (2015) A molecular switch in immunodominant HIV-1-specifci CD8 T cell epitopes shapes differential HLA-restricted escape Retrovirology doi: 10.1186/s12977-015-0149-5. (¶Equal contribution). Download

147. Straetemans, T., C. Berrevoets, M Coccoris, E. Treffers-Westerlaken, R Wijers, DK. Cole, V. Dardalhon, A. Sewell, N. Taylor, J. Verweij and R Debets (2015) Recurrence of melanoma following T-cell treatment: continued antigen expression in a tumour that evades T-cell recruitment. Molecular Therapy, 23, 396-406. Download

146. Tan M.P., A.B. Gerry, J.E. Brewer, L. Melchiori, J.S. Bridgeman, A.D. Bennett, N.J. Pumphrey, B.K. Jakobsen, D.A. Price, K. Ladell and A.K. Sewell (2015) TCR binding affinity governs the functional profile of cancer-specific CD8+ T cells. Clinical and Experimental Immunology, 180, 255-70. Download

145. Madura, F., P.J. Rizkallah, C.J. Holland, A. Fuller, A. Bulek, A.J Godkin, A.A.J. Schauenburg, D.K. Cole* and A.K. Sewell (2015) Structural basis for ineffective T-cell responses to MHC anchor residue improved ‘heteroclitic’ peptides. European Journal of Immunology, 45, 584-91. This article was highlighted the journal cover and was subject of a commentary entitled T-cell receptors: Tugging on the anchor for a tighter hold on the tumour-associated peptide EJI Feb 9th 2015. Download

144. Skowera, A, K. Ladell, J. McLaren, G. Dolton, K. Matthews, E. Gostick, D. Kronenberg-Versteeg, M. Eichmann, R. Knight, S. Heck, J. Powrie, P. Bingley, C. Dayan, J. Miles, A.K Sewell, D. Price, and M. Peakman (2015) β-cell-specific CD8 T cell phenotype in type 1 diabetes reflects chronic autoantigen exposure. Diabetes, 64, 916-25. Download

143. Knight, R., G. Dolton, D. Kronenberg-Versteeg, M. Eichmann, M. Zhao, G.C. Huang, K. Beck, D.K. Cole, A.K. Sewell, A. Skowera and M. Peakman (2015) A distinct immunogenic region of GAD65 is naturally processed and presented by human islet cells to cytotoxic CD8 T-cells. Clinical and Experimental Immunology, 179, 100-107. Download

142. Tungatt, K., V. Bianchi, M.l Crowther, W. E. Powell, A. J. Schauenburg, A.Trimby, M. Donia, A. Skowera, J. J. Miles, C. J. Holland, D. K. Cole, A. J. Godkin, M. Peakman, P. T. Straten, I. M. Svane, Garry Dolton¶ and A.K. Sewell¶ (2015) Antibody stabilization of peptide-MHC multimers reveals functional T-cells bearing extremely low affinity TCRs. Journal of Immunology, 194, 463-74 (¶Equal contribution). Download

141. Dolton, G., A. Lissina, A. Skowera, K. Ladell, K. Tungatt, E. Jones, D. Kronenberg-Versteeg, H. Akpovwa, J.M. Pentier, C.J. Holland, A.J. Godkin, D.K. Cole, M.A. Neller, J.J. Miles, D.A. Price, M. Peakman and A.K. Sewell (2014) Comparison of peptide-major histocompatibility comples tetramers and dextramers for the identification of antigen-specific T-cells. Clinical and Experimental Immunology 177, 47-63. This article was highlighted and received the journal cover. Download

140. Stepanek O, Prabhakar AS, Osswald C, King CG, Bulek A, Naeher D, Beaufils-Hugo M, Abanto M, Galati V, Hausmann B, Lang R, Cole DK, Huseb E, Sewell AK, Chakraborty AK, and Palmer E. (2014) Coreceptor-mediated Lck delivery to the TCR sets the antigen dwell-time threshold for central tolerance. Cell. 159, 333-45. This paper was the subject of Nature News & Views article “Tolerance lies in the timing” Nature 515, 502-503 (November 27th, 2014). Download

139. Motozono, C., N. Kuse, X. Sun, P.J. Rizkallah, A. Fuller, S. Oka, D.K. Cole, M. Takaguchi¶ and A.K. Sewell¶ (2014) Molecular basis of a dominant T-cell response to an HIV reverese transcriptase 8-mer epitope presented by the protective allele HLA-B*51:01. Journal of Immunology, 192, 3428-3434. (¶Equal contribution). Download

138. Bhati, M., D.K. Cole, J. McCluskey, A.K. Sewell and J. Rossjohn (2014) The versatility of the ab T-cell antigen receptor. Protein Science, 23, 260-72. Download

137. Cole, D.K., K.M. Miles, F. Madura, C.J. Holland, A.J. Schauenburg, A.J. Godkin, A.M. Bulek, A. Fuller, H.J. Akpovwa, P.G. Pymm, N. Liddy, M. Sami, Y. Li, P.J. Rizkallah, B.K. Jakobsen and A.K. Sewell (2014). TCR-peptide specificity overrides affinity enhancing TCR-MHC interactions. Journal of Biological Chemistry, 289, 628-38. Download

136. van den Berg, H.A., K. Ladell, K. Miners, B. Laugel, S. Llewellyn-Lacey, M. Clement, D.K. Cole, E. Gostick, L. Wooldridge, A.K. Sewell, J.S. Bridgeman and D.A. Price (2013). Cellular-level versus receptor-level response threshold hierarchies in T-cell activation. Frontiers in Immunology, 4:250. Download

135. Madura, F., P.J. Rizkallah, K.M. Miles, C. J. Holland, A.M. Bulek, A. Fuller, A.J.A. Schauenburg, J.J. Miles, N. Liddy, M. Sami, M. Houssain, B.M. Baker, B.K. Jakobsen, D.K. Cole and A.K. Sewell (2013) T-cell receptor specificity maintained by altered thermodynamics. Journal of Biological Chemistry, 288, 18766-18775. Download

134. Williams, J.P., P. Southern, A. Lissina, H. Christian, A. Sewell, R. Phillips, Q. Pankhurst and J. Frater (2013). Application of magnetic field hyperthermia and superparamagnetic iron oxide nanoparticles to HIV-1-specific T-cell cytotoxicity. International Journal of Nanomedicine 8, 2543-54. Download

133. Pentier, J.M., A.K. Sewell, and Miles J.J (2013). Advances in T-cell epitope engineering. Frontiers in Immunology 4:133 doi: 10.3389/fimmu.2013.00133. Download

132. Motozono C., J.J. Miles, Z. Hasan, H. Gatanaga, S.C. Meribe, D.A. Price, S. Oka, T. Ueno and A.K. Sewell (2013). CD8 T cell cross-reactivity profiles and HIV-1 immune escape in an HLA-B35-restricted immunodominant Nef epitope. PLoS One 8, e66152. Download

131. Challier, J., D. Bruniquel, A.K. Sewell and B. Laugel (2013) Adenosine and camp signaling skew human dendritic cell differentiation towards a tolerogenic phenotype with defective CD8+ T-cellpriming capacity. Immunology, 138:402-10. Download

130. Xu, W., D.M. Watts, M.C. Costanzo, X. Tang, L.A. Venegas, F. Jiao, A. Sette, J. Sidney, A.K. Sewell, L. Wooldridge, S. Makino, J.C. Morrill, C.J. Peters and J. Kan-Michell (2013). The nucleocapsid protein of rift valley fever virus is a potent human CD8+ T cell antigen and elicits memory responses. PLoS One, 8, e59210. Download

129. Ekeruche-Makinde, J. Miles, H.A. van den Berg, A. Skowera, A.J.A. Schauenburg, M.P. Tan, G. Dolton, J.M. Pentier, S. Llewellyn-Lacey, K.M. Miles, A.M. Bulek, M. Clement, T. Williams, D.K. Cole, J. Rossjohn, M. Peakman, D.A. Price, S.R. Burrow, L.Wooldridge and A.K. Sewell (2013). Peptide length determines the outcome of TCR/peptide-MHCI engagement. Blood, 121, 1112-23. Download

128. Knight, R.R, D. Kronenberg, M. Zhao, G.C. Huang, A. Bulek, L. Wooldridge, D.K. Cole, A.K. Sewell, M. Peakman and A. Skowera (2013). Human β-cell killing by autoreactive preproinsulin-specific CD8 T cells is predominantly granule-mediated with the potency dependent upon TCR avidity. Diabetes, 62, 205-13. Download

127. Welton, J.L., M.P. Morgan, S.M. Perez, M.D. Stone, B. Moser, A.K.Sewell, J. Turton and M Eberl (2012) Monocytes and γδ T cells control the acute phase response to intravenous zoledronate: insights from a phase IV safety trial. Journal of Bone and Mineral Research, 28, 464-71. Download

126. Matthews, P.C. Koyanagi, H. Kloverpris, M. Harndahl, A. Stryhn, T. Akahoshi, H. Gatanaga, S. Oka, C. Molina, H. Ponce, S. Rios, D. Cole, J. Carlson, R. Payne, A. 126. Ogwu, A. Bere, T. Ndung'u, K. Gounder, F. Chen, L. Riddell, G. Luzzi, R. Shapiro, C. Brander, B. Walker, A. Sewell, G. Teran, D. Heckerman, E. Hunter, S. Buus, M. Takiguchi, and P. Goulder (2012) Differential clade-specific HLA-B*3501 association with HIV-1 disease outcome is linked to immunogenicity of a single Gag epitope. Journal of Virology, 86, 12643-54. Download

125. Neller, M.A., A.K. Sewell, S.R. Burrows and J.J. Miles (2012) Tracking the repertoire of human adult and neonatal T cells during ex vivo amplification (2012). British Journal of Haematology. 159, 370-379. Download

124. Gras, S. S.R., Burrows, S.J. Turner, A.K. Sewell, J. McCluskey and J Rossjohn (2012) A structural voyage towards understanding pf the MHC-I restricted immune response: lessons learnt and much to be learned. Immunological Reviews, 250, 61-68. Download

123. Cole, D.K., B. Laugel, M. Clement, D.A. Price, L. Wooldridge and A.K. Sewell (2012). The molecular determinants of CD8 co-receptor function. Immunology, 137, 139-48. Download

122. Ekeruche-Makinde, J., M. Clement, D.K. Cole, E.S.J. Edwards, K. Ladell, J.J. Miles, K.K. Matthews, A. Fuller, K.A. Lloyd, F. Madura, G.M. Dolton, J. Pentier, A. Lissina, E. Gostick, T.K. Baxter, B.M. Baker, P.J. Rizkallah, D.A Price, L. Wooldridge and A.K. Sewell (2012). T cell receptor optimized skewing of the T-cell repertoire can enhance antigen targeting. Journal of Biological Chemistry, 287, 37269-81. Download

121. Sewell AK (2012). Why must T cells be crossreactive? Nature reviews Immunology, 12, 669-677. Download

120. Holland, C.J., P.J. Rizkallah, S. Vollers, J.M. Calvo-Calle, F. Madura, A. Fuller, A.K. Sewell, L.J. Stern, A. Godkin and D.K. Cole (2012). Minimal conformational plasticity enables TCR crossreactivity to different MHC class II heterodimers. Scientific Reports 2, 629 | doi: 10.1038/srep00629. Download

119. Knight, R.R, D. Kronenberg, M. Zhao, G.C. Huang, A. Bulek, L. Wooldridge, D.K. Cole, A.K. Sewell, M. Peakman and A. Skowera (2012). Human β-cell killing by autoreactive preproinsulin-specific CD8 T cells is predominantly granule-mediated with the potency dependent upon TCR avidity. Diabetes doi: 10.2337/db12-0315

118. Neller, M.A., A.K. Sewell, S.R. Burrows and J.J. Miles (2012) Tracking the repertoire of human adult and neonatal T cells during ex vivo amplification (2012). British Journal of Haematology, DOI: 10.1111/bjh.12022. Download

117. Liddy, N, G. Bossi, K.J. Adams, A. Lissina, T.M. Mahon, N.J. Hassan, J. Gavarret, F.C. Bianchi, N.J. Pumphrey, K. Ladell†, E. Gostick, A.K. Sewell, N.M. Lissin, N.E. Harwood, P.E. Molloy, Y. Li, B.J. Cameron, M. Sami, E.E. Baston, P.T. Todorov, S.J. Paston, R.E. Dennis, J.V. Harper, S.M. Dunn, R. Ashfield, A. Johnson, Y. McGrath, G. Plesa, C.H. June, M.Kalos, D.A. Price, A. Vuidepot, D.D. Williams, D.H. Sutton, B.K. Jakobsen (2012) Monoclonal TCR-redirected tumour cell killing. Nature Medicine, 18, 980-7 (Nat Liddy is a Sewell PhD student). Download

116. Bulek, A.M. F. Madura, A. Fuller, C.J. Holland, A.J.A. Schauenburg, A.K. Sewell. P.J. Rizkallah and D.K. Cole (2012). TCR/pMHC optimized protein crystallization screen. Journal of Immunological Methods, 382, 203-210. Download

115. Cole, D.K., Gallagher, K, Lemercier, B, Holland, C.J, S. Junaid, J.P. Hindley, K. Wynn, E. Gostick, A.K. Sewell, A.M. Gallimore, K. Ladell, D.A. Price, M-L Gougeon and A. Godkin (2012) Modification of the carboxy-terminal flanking region of a universal influenza epitope alters CD4+ T-cell repertoire selection. Nature Communications, 3:665 DOI: 10.1038/ncomms1665. Download

114. Bulek, A.M, D.K. Cole, A. Skowera, G. Dolton, S. Gras, F. Madura, A. Fuller, J.J. Miles, E. Gostick, D.A. Price, J.W. Drijfhout, R.R. Knight, N. Lissin, P.E. Molloy, L. Wooldridge, B.K. Jakobsen, J. Rossjohn, M. Peakman, P.J. Rizkallah and A.K. Sewell (2012) Structural basis of human beta-cell killing by preproinsulin-specific CD8+ T-cells in type 1 diabetes. Nature Immunology, 13, 283-9. Download

113. Wooldridge, L., J. Ekeruche-Makinde, H.A. van den Berg, A. Skowera, J.J. Miles, M.P. Tan, G. Dolton, M. Clement, S. Llewellyn-Lacey, D.A. Price, M. Peakman and A.K. Sewell (2012) A single autoimmune T-cell receptor recognises over a million different peptides. Journal of Biological Chemistry, 287, 1168-77. Download

112. Bridgeman, J.S., A.K. Sewell, J.J. Miles, D.A. Price and D.K. Cole (2012) Structural and biophysical determinants of alpha beta T-cell antigen recognition, Immunology, 135, 1365-2567. Download

111. van den Berg, HA., C. Molina-Paris and A.K. Sewell (2011) Specific T-cell activation in an unspecific T-cell repertoire. Science Progress 94: 245-64.

110. Laugel, B., D.K. Cole, M. Clement, L. Wooldridge, D.A. Price and A.K. Sewell (2011). The multiple Roles of the CD8 co-receptor in T-cell biology: Opportunities for the selective modulation of self-reactive cytotoxic T-cells. Journal of Leukocyte Biology, 90, 1089-99. Download

109. Clement, M., K. Ladell, J. Ekeruche-Makinde, J.J. Miles, E.S.J. Edwards, G. Dolton, T. Williams, A.J.A. Schauenburg, D.K. Cole, S.N. Lauder, A.M. Gallimore, A.J. Godkin, S.R. Burrows, D.A. Price, L. Wooldridge* and A.K. Sewell* (2011) Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining. Journal of Immunology, 187, 654-63 (*Equal contribution). Download

108. Miles, K.M., J.J. Miles, F. Madura, D.K. Cole* and A.K. Sewell* (2010). Real time detection of peptide-MHC dissociation reveals that improvement of primary MHC-binding residues can have a minimal, or no, effect on stability. Molecular Immunology, 48, 728-32. (*Equal contribution). Download

107. Miles, J.J., A.M. Bulek, D.K. Cole, E. Gostick, A.J.A. Schauenburg, G. Dolton, V. Venturi, M.P. Davenport, M.P. Tan, S.R. Burrows, L. Wooldridge, D.A. Price, P.J. Rizkallah and A.K. Sewell (2010). Genetic and Structural Basis for Selection of a Ubiquitous T Cell Receptor Deployed in Epstein-Barr Virus Infection. PLoS Pathogens 6, e1001198. doi:10.1371/journal.ppat.1001198. Download

106. Tarbe M, I. Azcune, E. Balentová, J.J. Miles, E Edwards, K.M. Miles, P. Do, B.M. Baker, A.K. Sewell, J.M. Aizpurua, C. Douat-Casassus and S. Quideau (2010). Design, synthesis and evaluation of beta-lactam antigenic peptide hybrids; unusual opening of the beta-lactam ring in acidic media. Org. Biomol. Chem. 8, 5345-53. Download

105. Wooldridge, L., B. Laugel, J. Ekeruche, M. Clement, H van den Berg, D.A. Price and A.K. Sewell (2010) CD8 controls T cell crossreactivity. Journal of Immunology, 185, 4625-32. Download

104. Cole, D.K., E.S.J. Edwards, K.K. Wynn, M. Clement, J.J. Miles, K. Ladell, J. Ekeruche, K. Adams, A. Skowera, M. Peakman, L. Wooldridge, D.A. Price and A.K. Sewell (2010) Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T-cell recognition. Journal of Immunology, 185, 2600-10. Download

103. Schaubert, K.L., D.A. Price, J.R. Salkowitz, A.K. Sewell, J. Sidney, T.E. Asher, S.E. Blondelle, S. Adams, F.M. Marincola, A. Joseph, A. Sette, D.C. Douek, V. Ayyavoo, W. Storkus, M-Y. Leung, H.L. Ng, O.O. Yang, H. Goldstein, D.B. Wilson and J. Kan-Mitchell (2010). Generation of robust CD8+ T cell responses against subdominant epitopes in conserved regions of HIV-1 by repertoire mining with mimotopes. European Journal of Immunology, 40, 1950-1962. Download

102. Wooldridge L., M. Clement, A. Lissina, E.S. Edwards, K. Ladell, J. Ekeruche, R.E. Hewitt, B. Laugel, E. Gostick, D.K. Cole, R. Debets, C. Berrevoets, J.J. Miles, S.R. Burrows, D.A. Price and A.K. Sewell (2010). MHC class I molecules with Superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs. Journal of Immunology, 184, 3357-66. Download

101. Borbulevych, O.Y., K.H. Piepenbrink, B.E. Gloor, D.R. Scott, R.F. Sommese, D.K. Cole, A.K. Sewell and B.M. Baker (2009). T cell receptor cross-reactivity directed by antigen-dependent tuning of peptide-MHC molecular flexibility. Immunity, 31, 885-96. Download

100. Chen, J.L., A.J. Morgan, G. Stewart-Jones, D. Shepherd, G. Bossi, L. Wooldridge, S.L. Hutchinson, A.K. Sewell, G.M. Griffiths, P.A. van der Mewre, E.Y. Jones, A. Galione and V. Cerundolo (2010) Ca2+ Release from the Endoplasmic Reticulum of NY-ESO-1-Specific T Cells is Modulated by the affinity of TCR and by the use of CD8 coreceptor. Journal of Immunology, 184, 1829-39. Download

99. Walker, L.J, A.K. Sewell and P. Klenerman (2009) T cell sensitivity and the outcome of viral infection. Clinical and Experimental Immunology, 159, 245-55. Download

98. Horlock, C., B. Stott, J. Dyson, G. Ogg, T. McPherson, L. Jones, A.K. Sewell, L. Wooldridge, D.K. Cole, J. Stebbing and P. Savage (2009). ELISPOT and functional T cell analyses using HLA mono-specific target cells. Journal of Immunological Methods 350, 150-60. Download

97. Cole, D.K., F. Yuan, P.J Rizkallah, J.J. Miles, E. Gostick, D.A. Price, G.F Gao, B.K Jakobsen and A.K Sewell (2009). Germline-governed recognition of a cancer epitope by an immunodominat human T-cell receptor. Journal of Biological Chemistry 284, 27281-9. Download

96. Chouduri, K., M. Parker, D.K. Cole, A.M. Mipcic, M. Shaw, A.K. Sewell, T. Dong, K.G. Gould and P.A van der Merwe (2009) Peptide-MHC dimensions control proximal kinase-phosphate balance during T cell activation. Journal of Biological Chemistry, 284, 26096-105. Download

95. Varela-Rohena, A., B.K. Jakobsen, A.K. Sewell, C.H. June and J.L. Riley (2009) Are affinity-enhanced T cells the future of HIV therapy? HIV Therapy, 3, 105-8. Download

94. Jo, J., U Aichelle, N. Kersting, R. Klein, P. Aichele, E. Bisse, A. K Sewell, H.E. Blum, R. Bartenschlager, V. Lohmann and R. Thimme (2009) Analysis of CD8+ T-cell-mediated inhibition of hepatitis C virus replication using a novel immunological model. Gastroenterology, 136, 1391-401. Download

93. Wooldridge, L., A. Lissina, D.K. Cole, H. van den Berg, D.A. Price and A.K. Sewell (2008) Tricks with Tetramers: How to get the most from multimeric peptide-MHC. Immunology, 126, 147-64. Download

92. Lissina A., K. Ladell, A. Skowera, M. Clement, E. Edwards, R. Seggwiss, H. van den Berg, E. Gostick, K. Gallagher, E. Jones, J.J. Melenhorst, A.J. Godkin, M. Peakman, D.A. Price, L. Wooldridge* and A.K. Sewell* (2009) Protein kinase inhibitors substantially improve the physical detection of T-cells with peptide-MHC tetramers. Journal of Immunological Methods, 340, 11-24. Download

91. Varela-Rohena, A. P.E. Molloy, S. M. Dunn, Y. Li M. M. Suhoski, R.G. Carroll, A. Milicic, T. Mahon, D.H. Sutton, B.E. Laugel, R. Moysey, B.J. Cameron, A. Vuidepot, M.E. Purbhoo, D.K. Cole, R.E. Phillips, C.H. June, B.K. Jakobsen, J.L. Riley* and A.K. Sewell* (2008) Control of HIV-1 immune escape by CD8 T-cells expressing enhanced T-cell receptor Nature Medicine 14, 1390-5. (*equal contribution) Download

90. Skowera, A., R.J. Elps, R. Varela-Calvino, S. Arif, G.C. Huang, C. Van-Krinks, A. Zaremba, C. Rackham, J.S. Allen, T.I. Tree, M. Zhao, M. C.M. Dayan, A.K. Sewell, W. Unger, J.W. Drijfhout, F. Ossendorp, B.O. Roep and M. Peakman (2008) CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsupn epitope. Journal of Clinical Investigation, 118, 3390-3402. Download

89. Melenhorst, J.J., P. Scheinberg, A. Lissina, P.K. Chattopadhyay, E. Gostick, D.K. Cole, L. Wooldridge, H.A. van den Berg, E. Bornstein, N.F. Hensel, D.C. Douek, M. Roederer, A.K. Sewell, A.J. Barret and D.A. Price (2008) Detection of low avidity CD8+ T cells with coreceptor-enhanced peptide-MHC class I tetramers. Journal of Immunological Methods, 338, 31-9. Download

88. Chattopadhyay, P.K., J.J. Melenhorst, K. Ladell, E. Gostick, P. Scheinberg, A. J Barrett, L. Wooldridge, M. Roederer, A.K. Sewell, D.A. Price (2008). Techniques to improve the direct ex vivo detection of low frequency antigen-specific CD8+ T cells with peptide-major histocompatibility complex class I tetramers. Cytometry 73, 1001-9. Download

87. Scriba, T.J., S. Sierro. E.L. Brown, R.E. Phillips, A.K. Sewell and R.C. Massey (2008) The S. aureus Eap protein activates expression of proinflammatory cytokines by human leukocytes. Infection and Immunity, 76, 2164-68. Download

86. Weichsel, R, C. Dix, L. Wooldridge, M. Clement, A. Fenton-May, A.K. Sewell, J. Zezula, E. Greine, E. Gostick, D.A. Price, H. Einsele and R. Seggewis (2008) Profound inhibition of antigen-specific T cell effector functions by dasatinib. Clinical Cancer Research, 14, 2484-91. Download

85. Kasprowicz, V. S.M. Ward, A. Turner, A. Grammatikos, B. Nolan, L. Lewis-Ximenez, C. Sharp, J. Woodruff, V. Fleming, S. Sims, B.D. Walker, A. Sewell, G M. Lauer and P Klenerman (2008). Defining the directionapty and quapty of CD8+ T cell heterologous immunity in hepatitis C virus infection. Journal of Clinical Investigation, 118, 1143-53. Download

84. Cole, D.K., S.M. Dunn, M. Sami, J.M. Boulter, A.K. Sewell and B.K. Jakobsen (2008) Co-engagement of the CD8α/α co-receptor to peptide-major histocompatiliipty complexes: The effect of T-cell receptor docking on CD8 binding. Molecular Immunology, 45, 2700-9. Download

83. Massey, R.C., T.J. Scriba, E.L. Brown, R.E. Philpps and A.K. Sewell (2007) The use of peptide-MHC tetramer technology to study interactions between S. aureus proteins (TSST-1 and Eap) and human cell. Infection and Immunity, 75, 5711-5. Download

82. Laugel, B., H.A. van den Berg, E. Gostick, D.K. Cole, L. Wooldridge, J. Boulter, A. Milicic, D.A. Price and A.K. Sewell (2007) Different T cell receptor affinity thresholds and CD8 coreceptor dependence govern cytotoxic T lymphocyte activation and tetramer binding properties. Journal of Biological Chemistry, 282, 23799-23810. Download

81. van den Berg, H., L. Wooldridge, B. Laugel and A.K. Sewell (2007) Coreceptor CD8-driven Modulation of T-Cell Antigen Specificity. Journal of Theoretical Biology 249, 395-408. Download

80. Yan, F., T. Georgiou, T. Hilton, E. Gostick, D.A. Price, A.K. Sewell, R. Moysey, J. Gavarret, A. Vuidepot, M. Sami, J.I. Bell, G.F. Gao, P.J. Rizkallah and B.K. Jakobsen (2007) Crystapzation and preliminary X-ray structural studies of a Melan A pMHC-TCR complex. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 63, 758-60. Download

79. M.A. Purbhoo, M. A., Y. p, D. H. Sutton, J. E. Brewer, E. Gostick, G. Bossi, B. Laugel, R. Moysey, E. Baston, N. Liddy, B. Cameron, A.D. Bennett, R. Ashfield, A. Mipcic, D.A. Price, B. J. Classon, A.K. Sewell and B.K. Jakobsen (2007) The A2- hTERT540-548 peptide is not detected on tumor cells by a CTL clone or a high affinity TCR. Molecular Cancer Therapeutics, 6, 2081-91. Download

78. Wooldridge, L., S.L. Hutchinson, A. Lissina, J. Vernazza, E. Gostick, B. Laugel, S. Tafuro, A. Oxenius, F. Mirza, P. R. Dunbar, J.M. Boulter, Meir Glick, V. Cerundolo, H. A. van den Berg, D. A. Price and A.K. Sewell (2007) Enhanced immunogenicity of CTL antigens through mutation of the CD8 binding MHC class I invariant region. European Journal of Immunology, 37, 1323-1333. Download

77. Schaubert, K., D.A. Price, N. Frahn, J. Li, H.L. Ng, A. Joseph, E. Paul, B. Majumder, V. Ayyavoo, E. Gostick, S. Adams, F. M. marincola, A.K. Sewell, M. Atfeld, J.M. Brenchley, D.C. Douek, O.O. yang, C. Brander, H. Goldstein and J. Kan-Mitchell (2007) Availabipty of a diversely avid CD8+ T cell repertoire specific for the subdominant HLA A2-restricted HIV-1 Gag p2419-27 epitope. Journal of Immunology, 178, 7756-66. Download

76. Laugel, B., D.A. Price, A. Milicic and A.K. Sewell (2007) CD8 exerts differential effects on the deployment of cytotoxic T lymphocyte effector functions. European Journal of Immunology, 37, 905-913. Download

75. Boulter, J.M., N Schmits, A.K. Sewell, A.J. Godkin, M.F. Bachmann and A.M. Galimore (2007) A very short half-pfe TCR-pMHC interaction can mediate a potent agonist T cell response. European Journal of Immunology, 37, 798-806. Download

74. Gostick, E., D.K. Cole, S. L. Hutchinson, L. Wooldridge, S. Tafuro, B. Laugel, A. Lissina, A. Oxenius, J.M. Boulter, D. A. Price and A. K. Sewell (2007) Functional and biophysical characterization of an HLA A*6801-restricted HIV-specific T cell receptor. European Journal of Immunology, 37, 479-86. Download

73. Cole, D.K., N.J. Pumphrey, J.M. Boulter, M. Sami, J.I. Bell, G. F. Gao, A.K. Sewell and Bent K. Jakobsen (2007) Human T-Cell Receptor Binding Affinity is Governed by Major Histocompatibipty Complex Class Restriction (2007). Journal of Immunology, 178, 5727-34. Download

72. Mitchell, M.S., T. A. Lund, A. K. Sewell, F. M. Marincola, E. Paul, K. Schroder, D. B. Wilson and J. Kan-Mitchell (2007) The cytotoxic T cell response to peptide analogs of the HLA-A*0201-restricted MUC1 signal sequence epitope, M1.2. Cancer Immunology and Immunotherapy, 56, 287-301. Download

2001-6 Wellcome Trust Senior Fellow, University of Oxford.

71. Fleming, V., Feil, E., A. K. Sewell, N. Day, A. Buckling and R. C. Massey (2006) Agr interference between clinical Staphylococcus aureus strains in an insect model of virulence Journal of Bacteriology, 188, 7686-8. Download

70. Wooldridge, L., T. J. Scriba, A. Milicic, E. Gostick, D. A. Price, R. E. Phillips and A. K. Sewell (2006). The choice of anti-CD8 or anti-CD4 antibody clone profoundly affects staining with peptide-MHC class I and class II tetramers European Journal of Immunology, 36, 1847-55. Download

69. B. Laugel, D.A. Price and A.K. Sewell (2006) TCR-directed therapeutics, Nature Biotechnology, 24, 615-6. Download

68. Scriba, T.J., M. Purbhoo, C. L. Day, N. Robinson, S. Fidler, J. Fox, J. N. Weber, P. Klenerman, A. K. Sewell and R.E. Phillips (2005). Ultra-sensitive detection and phenotyping of CD4+ T cells with optimized HLA class II tetramer staining Journal of Immunology, 175, 6334-43. Download

67. Rezvani, K, D.A Price, J. Brenchley, Y. Kipcal, E. Gostick, A.K. Sewell, G. Sconocchia, Roger Kurlander, D.C. Douek and John Barrett (2005). Transfer of defined T cell clones with graft-versus-leukemia (GVL) activity from donor to recipient in stem cell transplantation: identification, quantification and characterization. Clinical Cancer Research, 11, 8799-8807. Download

66. Price, D.A., J.M. Brenchley, L.E. Ruff, M. R. Betts, B.J. Hill, M. Roederer. R. Koup, D.R., S.A. Migueles, E. Gostick, L. Wooldridge, A.K. Sewell, M. Connors and D.C. Douek (2005) Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistant DNA viruses. Journal of Experimental Medicine, 202, 1349-61. Download

65. Milicic, A. D.A. Price, P. Zimbwa, B. L. Booth, H.L. Brown, P.J. Easterbrook, K. Olsen, N. Robinson, U. Gileadi, A.K. Sewell, V. Cerundolo, and R.E. Phillips (2005) CD8+ T cell flanking mutations disrupt proteasomal processing of HIV-1 Nef. Journal of Immunology, 175, 4618-4626. Download

64. Wooldridge, L., H. A. van den Berg, M. Glick, E. Gostick, J.M. Brenchley, D.C. Douek, D.A. Price and A.K. Sewell (2005). Interaction between the CD8 coreceptor and MHC class I stabilizes TCR-antigen complexes at the cell surface. Journal of Biological Chemistry, 280, 27491-27501. Download

63. Chen, J-L., G. Stewart-Jones, G. Bossi, N. M. Lissin, L. Wooldridge , E. Choi, G. Held, P.R. Dunbar, R. M. Esnouf, M. Sami, J. M. Boulter, P. Rizkallah, C. Renner, A.K. Sewell, P.A. van der Merwe, B.K. Jakobsen, G. Griffiths, E.Y. Jones and V. Cerundolo (2005) Structural and kinetic basis for heightened immunogenicity of T-cell vaccines Journal of Experimental Medicine, 201, 1243-55. Download

62. Leslie, A., D. Kavanagh, I. Honeyborne, K. Pfafferott, C. Edwards, T. Pillay, L. Hilton, C. Thobakgale, D. Ramduth, R. Draenert, S. Legall, G. Luzzi, A. Edwards, C. Brander, A.K. Sewell, S. Moore, J. Mullins, C. Moore, S. Mallal, N. Bhardwaj, K. Yusim, R. Phillips, P. Klenerman, B. Korber, P. Kiepiela, B. Walker and P. Goulder (2005) Transmission and accumulation of CTL escape variants explains apparent negative selection in HIV J. Exp. Med. 201, 891-902. Download

61. Molloy, P.E., A. K. Sewell and B. K. Jakobsen (2005) Soluble T cell receptors: novel immunotherapies. Current Opinion in Pharmacology, 5, 438-43. Download

60. Hewitt, R.E., A. Lissina,, A. E. Green, E. S. Slay, D. A. Price and A.K. Sewell (2005) The bisphosphonate acute phase response: Rapid and copious production of proinflammatory cytokines by peripheral blood γδ T cells in response to aminobisphosphonates is inhibited by statins Clinical and Experimental Immunology, 139, 101-111. Download

59. Laugel B., J.M. Boulter, N. Lissin, A. Vuidepot, Y. Li, Emma Gostick, L. E. Crotty, D.C. Douek, J. Hemelaar, D.A. Price, B.K. Jakobsen and A.K. Sewell (2005) Design of soluble recombinant T cell receptors for antigen targeting and T cell inhibition. Journal of Biological Chemistry, 280, 1882-1892. Download

58. Green, A. E., A. Lissina, S. L. Hutchinson, R. E. Hewitt, B. Temple, D. James, J. M. Boulter, D. A. Price and A. K. Sewell (2004) Recognition of non-peptide antigens by human Vγ9Vδ2 T cells requires contact with cells of human origin. Clinical and Experimental Immunology, 136, 472-82. Download

57. Gao B., A. Williams, Sewell A and T. Elliott (2004) Generation of a functional, soluble tapasin protein from an alternatively spliced mRNA. Genes Immun. 5, 101-8. Download

56. Wooldridge, L., S. L. Hutchinson, E. M. Choi, A. Lissina, E. Jones, F. Mirza, P. R. Dunbar, D. A. Price, V. Cerundolo, A. K. Sewell (2003) Anti-CD8 antibodies can inhibit or enhance peptide-MHC class I (pMHCI) multimer binding: This is paralleled by their effects on cytotoxic T lymphocyte activation and occurs in the absence of an interaction between pMHCI and CD8 on the cell surface. Journal of Immunology, 171, 6650-6660. Download

55. Choi, E. M-L., J-L. Chen, L. Wooldridge, M. Sapo, A. Lissina, N. Lissin, I. F. Hermans, J. D. Silk, F. Mirza, M. J. Palmowski, P. R. Dunbar, B. K. Jakobsen, A. K. Sewell and V. Cerundolo (2003) High avidity antigen specific CTL identified by CD8 independent tetramer staining. Journal of Immunology, 171, 5116-5123. Download

54. Green A, Hutchinson S, Boulter J, Lissina A, Temple B, Price D and Sewell A (2003). Activation of Vgamma9Vdelta2 T cells requires contact with a cell of human origin. Immunology, 110: 120-1.

53. Hutchinson, S. L. L. Wooldridge, S. Tafuro, B. Laugel, M. Glick, J. M. Boulter, B. K. Jakobsen, D. A. Price and A. K. Sewell (2003) The CD8 T cell coreceptor exhibits disproportionate biological activity at extremely low binding affinities. Journal of Biological Chemistry, 278, 24285-93. Download

52. Wooldridge, L. and A. Sewell (2002) HIV strategically targets HIV-specific T cells. Trends in Immunology, 23, 474. Download

51. Oxenius, A., A. K. Sewell, S. J. Dawson, H. F. Guenthard, G. M. Gillespie, C. Fagard, B. Hirschel, Rodney E. Phillips and David A. Price (2002) Functional discrepancies in HIV-specific CD8+ T lymphocyte populations are related to plasma virus load. Journal of Clinical Immunology, 22, 363-374. Download

50. Price, D. A and A. K. Sewell (2002) Quantitative clonotypic analysis of antigen-specific T-cell responses. Trends in Immunology, 23, 336-337. Download

49. Glick, M., D. A. Price, A-L. Vuidepot, T. B. Andersen, S. L. Hutchinson, A. K. Sewell, J. M. Boulter, A. Oxenius, P. R. Dunbar, V. Cerundolo, J. I. Bell W G. Richards and B. K. Jakobsen (2002) CD8+ T cell antagonists based on 2 microglobulin Journal of Biological Chemistry, 227, 20840-20846. Download

48. Sewell, A. K. (2002) Solving the mystery: CD8β delivers the TCR to lipid rafts. Trends in Immunology, 23, 124. Download

47. Kelleher, A. D., A. K. Sewell and D. A. Price (2002) Dyslipidaemia due to retroviral protease inhibitors. Nature Medicine, 8, 308-9. Download

46. Sewell, A. K. (2002) Breaking the kinetic window of T cell activation. Trends in Immunology, 23, 67. Download

45. Sewell, A. K., Bruce L. Booth Jr., Vincenzo Cerundolo, Rodney E. Phillips and David A. Price (2001). Differential processing of HLA A2-restricted HIV-1 cytotoxic T lymphocyte epitopes. Viral Immunology, 15, 193-196.

44. Sewell, A. K. and D. A. Price (2001). An inter-species difference in CD8. Trends in Immunology, 22, 595. Download

43. Purbhoo, M. A., J. Boulter, D. A. Price, C. S. Hourigan, P. R. Dunbar, K. Olsen, S. Dawson, B. K. Jakobsen, R. E. Phillips, J. I. Bell and A. K. Sewell (2001). The human CD8 coreceptor effects cytotoxic T cell activation and antigen sensitivity primarily by mediating complete phosphorylation of the T cell receptor zeta chain Journal of Biological Chemistry, 276, 32786-92. Download

42. Kellerher, A. D., B. L. Booth, A. K. Sewell, A. Oxenius, V. Cerundolo, A. J. McMichael, R. E. Phillips and D. A. Price (2001). The effects of retroviral protease inhibitors on proteasome function and processing of HIV-derived MHC class I-restricted cytotoxic T lymphocyte epitopes. AIDS Research and Human Retroviruses, 17, 1063-6.

41. Xu, XN, M. A. Purbhoo, N. Chen, J. Mongkolsapaya, J. H. Cox, U. Meier, S. Tafuro, P. R. Dunbar, A. K. Sewell, C. S. Hourigan, V. Appay, V. Cerundolo, A. J. McMichael and G. R. Screaton (2001). A novel approach to antigen-specific deletion of CTL with minimal cellular activation using alpha three domain mutants of MHC class I/peptide complexes. Immunity, 14, 591-602. Download

40. Oxenius, A., D. A. Price, S. J. Dawson, T. Tun, Phillips, R. E. and A. K. Sewell (2001). Cross-staining of cytotoxic T lymphocyte populations with peptide-MHC class I multimers of natural HIV-1 variant antigens. AIDS, 15, 121-123.

39. Sewell, A. K. and D. A. Price (2001). Dendritic cells and transmission of HIV-1. Trends in Immunology, 22, 173-175. Download

38. Hjorth-Sorensen, B., E. R. Hoffman, N. M. Lissin, A. K. Sewell and B. K. Jakobsen (2001) Activation of heat shock transcription factor in yeast is not influenced by the levels of expression of heat shock proteins. Molecular Microbiology, 39, 914-23. Download

1996-2001 Postdoc, University of Oxford

37. Price, D. A., A. Oxenius, P. J. Easterbrook, C. A. O’Callaghan, A. D. Kelleher, J. A. Whelan, G. Sontag, A. K. Sewell and R. E. Phillips (2000). Highly active antiretroviral therapy for primary HIV-1 infection preserves immune function of virus-specific T lymphocytes. Quarterly Journal of Medicine, 93, 769-70.

36. Sewell, A. K. (2000) Immunity to Human Immunodeficiency virus: Current issues Immunology News, 7.4, 17.

35. Sewell, A. K., and K. Whelan (2000). The role of dendritic cells in HIV-1 infection. Immunology News, 7.4, 22-23.

34. Sewell, A.K., D.A. Price, A. Oxenius, A. D. Kelleher and R. E. Phillips (2000). Cytotoxic T Lymphocyte Responses to HIV: Control and Escape. Stem Cells 18, 230-144.

33. Sewell, A. K. (2000) Does terminal replicating image xeroxing spell the end for monoclonal antibodies? Immunology News 7.2, 35.

32. Sewell, A. K. (2000). HIV-1: Fooling the immune system. Immunology News, 7.2, 31-33.

31. Sewell, A. K.*, C-L. Lin*, G. Gao, K. Whelan, R. E. Philpps and J. A. Austyn (2000). Macrophage tropic HIV induces and exploits dendritic cell chemotaxis. Journal of Experimental Medicine, 192, 587-594.

30. Oxenius, A., D. A. Price, P. J. Easterbrook, C. A. O'Callaghan, J. A. Whelan, A.A. Kellerher, A. K. Sewell and R. E. Phillips (2000). Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ lymphocytes Proc. Natl. Acad. Sci. USA, 97, 3382-3387.

29. Gileadi, U., H. T. Teisserenc, B. L. Booth, P. R. Dunbar, A. K. Sewell, J. Trowsdale, R. E. Phillips and V. Cerundolo (1999). Generation of an immunodominant cytotoxic T lymphocyte epitope is determined by Proteasome Subunit Composition and Stabipty of the Antigenic Protein. Journal of Immunology, 163, 6045 – 6052.

28. Whelan, J.A., P.R. Dunbar, D.A. Price, M.A. Purbhoo, F. Lechner, G.S. Ogg, G. Griffiths, R.E. Phillips, V. Cerundolo and A.K. Sewell (1999) Specificity of cytotoxic T lymphocyte interactions with peptide-MHC class I tetrameric complexes is temperature dependent. Journal of Immunology, 163, 4342 – 4348.

27. Sewell, A. K., D. A. Price, H. Teisserenc, B. L. Booth, U. Gileadi, R. E. Phillips and V. Cerundolo (1999) IFN- exposes a cryptic cytotoxic T lymphocyte epitopes in HIV 1 reverse transcriptase Journal of Immunology, 162, 7075-9.

26. Sewell, A. K., U. C. Gerth, D. A. Price, M. A. Purbhoo, J. M. Boulter, G. F. Gao, J. I. Bell, R.E. Phillips and B. K. Jakobsen (1999). Antagonism of cytotoxic T lymphocyte activation by soluble CD8. Nature Medicine, 5, 399-404.

25. Price, D. A., P. Klenerman, B. L. Booth, R. E. Phillips and A. K. Sewell (1999). Cytotoxic T lymphocytes, -chemokines and antiviral immunity. Immunology Today, 20, 212-216.

24. Wilson, J. D. K., G.S. Ogg, R. L. Allen, P.J.R. Goulder, A. Kelleher, A. K. Sewell, C. A. O'Callaghan, S. L. Rowland-Jones and A. J. McMichael (1998). Opgoclonal expansions of CD8+ T cells in chronic HIV infection are antigen specific. Journal of Experimental Medicine, 188, 785-790.

23. Lewis, J. W., A. K. Sewell, D. A. Price and T. Elliot (1998). HLA-A*0201 presents TAP-dependent epitopes to CTL in the absence of tapasin. European Journal of Immunology, 28, 3214-3220.

22. Price, D. A., U.C. Meier, P. Klenerman, M.A. Purbhoo, R.E. Phillips and A. K. Sewell (1998). The influence of antigenic variation on cytotoxic T lymphocyte responses in HIV-1 infection. Journal of Molecular Medicine, 76, 699-708.

21. Price D. A., Goulder P. J. R., Klenerman, P., Sewell, A. K., Easterbrook, P. J., Troop, M., Bangham, C. R. M. and Phillips, R. E. (1998) Positive selection mediated by cytotoxic T lymphocytes influences HIV-1 evolution during primary infection. Immunology Letters 56, 438.

20. Price, D.A., A.K. Sewell, T. Dong, R. Tan, P.J.R. Goulder, S.L. Rowland-Jones and R.E. Philpps (1998). Antigen-specific release of -chemokines by anti-HIV-1 cytotoxic T lymphocytes. Current Biology, 8, 355-358.

19. Purhboo, M. A., A. K. Sewell, P. Klenerman, P.J.R. Goulder, B. Jakobsen, K.L. Hilyard, J. I. Bell and R.E. Phillips (1998). Copresentation of natural HIV-1 agonist and antagonist ligands fails to induce the TCR signalling cascade. Proc. Natl. Acad. Sci. USA. 95, 4527-4532.

18. Sewell, A. K., G.C. Harcourt, P.R.J. Goulder, D.A. Price and Phillips, R. E. (1997). Cytotoxic T lymphocyte antagonism by natural peptide ligands requires simultaneous presentation of the agonist and antagonist peptides. European Journal of Immunology, 27, 2323-2329.

17. Goulder, P. J. R., A. K.Sewell, D. Lallo, D.A.Price, J. Whelan, J. Evans, G. Taylor, G. Luzzi, P. Giangrande, R.E. Phillips and A.J. McMichael (1997) Patterns of immunodominance in HIV-1-specific cytotoxic T lymphocyte responses in two HLA-identical siblings with HLA-A*0201 are influenced by epitope mutation. Journal of Experimental Medicine, 185 1423-1433.

16. Price, D. A., P.J.R. Goulder, ., P. Klenerman, A.K. Sewell, P.J. Easterbrook, M. Troop, C.R.M. Bangham and R. E. Phillips (1997). Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection. Proc. Natl. Acad. Sci. USA 94, 1890-1895.

1991-1995 Postdoc & Faculty, University of Utah

15. Winge, D. R. A.K. Sewell, W. Yu, J.L. Thorvaldsen, F. Yokoya and R. Farrell (1997). "Metal Ion Stress in Yeast" in Metal Ions in Gene Regulation , eds S. Silver and W. Walden, Chapham & Hall, New York. p279-315.

14. Thorvaldsen, J.L., R. Mehra, A.K Sewell, and D.R. Winge (1995). Analysis of copper-induced metallothionein expression using autonomously replicating plasmids in Candida glabrata. Yeast, 11, 1501-1511.

13. Sewell, A.K., F. Yokoya, W. Yu, T. Miyagawa, T. Murayama and D. R. Winge (1995). Mutated yeast heat shock transcription factor exhibits elevated basal transcriptional activation and confers metal resistance. J. Biol. Chem. 270, 25079-25086.

12. Sewell, A.K., Yokoya, F., Miyagawa, T., Murayama, T. and Winge, D. R. (1995). Role of heat shock transcription factor in metal resistance in yeast. J. Cell. Bioc. 21A, 262.

11. Sewell, A.K., L.T. Jensen, J.C. Erickson, R.D. Palmitter and D.R. Winge (1995). Bioactivity of Metallothionein-3 Correlates with its Unique Domain rather than Metal Binding Properties. Biochemistry , 34, p4740-47407.

10. Thorvaldsen, J.L., A.K. Sewell, A. Tanner, J. Peltiers, I.J. Pickering, G. George and Winge, D. R. (1994). Mixed Cu(I), Zn(II) Coordination in the DNA Binding Domain of the AMT1 Transcription Factor from Candida glabrata. Biochemistry, 33, p9566-9577.

9. Yu, W., V. Santhanagopalan, A.K. Sewell, L.T. Jensen and D.R. Winge (1994). "Dominance of Metallothionein in Metal Ion Buffering in Yeast Capable of Synthesis of (EC)nG Isopeptides." Journal of Biological Chemistry, 269, 21010-21015.

8. Erickson, J.C. A.K. Sewell, L. T. Jensen, D.R. Winge and R.D. Palmitter (1994). Enhanced Neurotrophic Activity in Alzheimer's Disease Cortex is not associated with down-regulation metallothionein-III (GIF). Brain Research 649, 297-304. 7. Michelsen, J.W., A.K. Sewell, H.A. Louis, J.I. Olsen, D.R. Davis, D.R. Winge and M.C. Bekerley (1994). Mutation Analysis of the Metal Sites in a LIM domain. J. Biol. Chem. 269, p11108-11113.

6. Macreadie, I.G., A.K. Sewell and D.R. Winge (1994) "The role of metallothionein in Metal Resistance in Yeast" In Metal ions in Fungi eds. G. Winkleman and D.R. Winge, Marcel Dekker. p279-310.

5. Thorvaldsen, J.L., A.K. Sewell, C. McCowen and D.R. Winge (1993) "Regulation of Metallothionein Genes by ACE1 and AMT1 Transcription Factors." J. Biol. Chem. 268, p12512-12518.

PhD. University of Liverpool

4. Tomsett, A.B., A.K. Sewell, S.J Jones, J.R. deMiranda and D.A Thurman (1992) "Metal binding proteins and metal-regulated gene expression in higher plants." In Inducible Plant Proteins, ed. J. L. Wray, Cambridge University Press. p1-24.

3. Tomsett, A.B, A.K. Sewell, S.J. Jones, J.R. deMiranda and D.A Thurman (1991) Metal-regulated gene expression in higher plants. J. Experimental Botany 42, 20-21.

2. Thurman, D.A., D. Salt, A.K. Sewell, M. Thomas, J.R. deMiranda and A.B. Tomsett (1988) Copper inducible Proteins and Genes in Mimulus guttatus. J. Cellular Biochemistry, 12D p342.

1. Salt, D.E., D.A. Thurman, A.B Tomsett and A.K. Sewell (1989) "Copper-inducible phytochelatins of Mimulus guttatus." Proceedings of the Royal Society of London, Series B 236, 79-89.