T Cell Recognition

TCR pMHC CD8

At the heart of practically every T-cell response is the interaction between the T-cell receptor (TCR) and peptide-major histocompatibility complexes (pMHC) expressed on the surface of most cell types which creates an interface between the T-cell and the target cell. This interface is further stabilized by other TCR/pMHC interactions and a number of co-receptor and co-binding molecules. This creates a polyvalent link between T-cell and target cell that allows a number of different signalling events to take place which lead to an appropriate immune response.