Bruce MacLachlan

Bruce MacLachlan

2012-present: I am currently a PhD student funded by a 4 year studentship from Cancer Research UK. My project, supervised by Dr Andrew Godkin and Dr David Cole, focuses on the presentation of tumour associated antigens on MHC class II molecules to CD4+ T cells. We are interested in describing the structural and biophysical characteristics of the CD4+ T cell response to a colorectal cancer antigen currently being targeted for use as a cancer vaccine. In addition, we are interested in describing the molecular role of a negative regulator of T cell activation which has been shown to be upregulated in CD4+ T cells extracted from human colorectal cancer patients.

2009-2012: Graduated with a first class honours degree in Biochemistry from Imperial College London. During my degree I developed an interest in structural biology and immunology. As part of my final year, I undertook a research project studying protein complexes involved in DNA damage repair. Specifically, I analysed the human BRCA2 protein and its interaction with RAD51 via negative stained transmission electron microscopy. Mutations within the BRCA2 gene have potent implications in hereditary breast and ovarian cancers.