Dr Bruno Laugel - Publications

Journal Publications

15 ) Wooldridge, L., Clement, M., Lissina, A., Edwards, E.S., Hewitt, R.E., Laugel, B., Gostick, E., Cole, D.K., Debets, R., Berrevoets, C., Miles, J.J.,, Burrows, S.R., Price, D.A. and Sewell, A.K. (2010). Major histocompatibility complex class I molecules with super-enhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate cytotoxic T lymphocytes. J Immunol 184, 3357-66.

14) Varela-Rohena A., Molloy P.E., Dunn S.M., Li Y., Suhoski M.M., Carroll R. G., Milicic A., Mahon T., Sutton D. H., Laugel B., Moysey R., Cameron B.J., et al. (2008). Control of HIV-1 immune escape by CD8 T-cells expressing enhanced T-cell receptor. Nat Med 14, 1390-1395.

13) van den Berg, H. A., Wooldridge, L., Laugel, B., and Sewell, A.K. (2007). Coreceptor CD8-driven modulation of T cell antigen receptor specificity. J Theor Biol 249, 395-408.

12) Purbhoo, M.A., Li, Y., Sutton, D.H., Brewer, J.E., Gostick, E., Bossi,G., Laugel, B., Moysey, R., Baston, E., Liddy, N., Cameron, B., Bennett, A.D. et al. (2007). The HLA A2-hTERT540-548 peptide is not detected on tumor cells by a CTL clone or a high affinity TCR. Mol Cancer Ther 7, 2081-2091.

11) Laugel, B., van den Berg, H. A., Gostick, E., Cole, D.K., Boulter, J.M., Milicic, A., Price, D.A., and Sewell, A.K. (2007). Different T cell receptor affinity thresholds and CD8 coreceptor dependency define cytotoxic T lymphocyte tetramer staining and activation. J Biol Chem 282, 23799-23810.

10) Wooldrige, L., Lissina, A., Vernazza, J., Gostick, E., Laugel, B, Hutchinson, S. L., Mirza, F., Dunbar, P. D., et al. (2007). Enhanced immunogenicity of cytotoxic T lymphocyte antigens through mutations of the major histocompatibility complex class I invariant region. Eur J of Immunol 37, 1323-1333.

9) Laugel, B., Price, D.A., Milicic, A., and Sewell, A.K. (2007). CD8 exerts differential enhancing effects on the deployment of cytotoxic T lymphocyte effector functions. Eur J Immunol 37, 905-913.

8) Gostick, E., Cole, D.K., Hutchinson, S., Wooldridge, L., Tafuro, S., Laugel, B., Lissina, A., Oxenius, A., Boulter, JM., Price, D.A., and Sewell, A.K. (2007) Functional and biophysical characterization of an HLA A*6801-restricted HIV-specific T cell receptor. Eur J of Immunol 37, 479-486.

7) Wooldrige, L., Scriba, T.J., Milicic, A., Laugel, B., Gostick, E., Price, D.A., Phillips, R.E., and Sewell, A.K. (2006). Anti co-receptor antibodies profoundly affect staining with peptide-MHC class I and class II tetramers. Eur J Immunol 36, 1847-1855.

6) Laugel, B., Price, D. A., and Sewell, A. K. (2006). On the path to TCR-directed therapeutics. Nature Biotechnol 24, 615-616.

5) Wooldridge, L., van den Berg, H. A., Glick, M., Gostick, E., Laugel, B.,Hutchinson, S. L., Milicic, A., Brenchley, J. M., Douek, D. C., Price, D. A., and Sewell, A. K. (2005). Interaction between the CD8 coreceptor and MHC class I stabilizes TCR-antigen complexes at the cell surface. J Biol Chem 280, 27492-27501.

4) Laugel, B., Boulter, J. M., Lissin, N., Vuidepot, A., Li, Y., Gostick, E., Crotty, L. E., Douek, D. C., Hemelaar, J., Price, D. A., et al. (2005). Design of soluble recombinant T cell receptors for antigen targeting and T cell inhibition. J Biol Chem 280, 1882-1892.

3) Laugel B.¶ Francez-Charlot, A., Van Gemert, A., Dubarry, N., Wiorowski, F., Castanie-Cornet, M. P., Gutierrez, C., and Cam, K. (2003). RcsCDB His-Asp phosphorelay system negatively regulates the flhDC operon in Escherichia coli. Mol Microbiol 49, 823-832.

2) Hutchinson, S. L., Wooldridge, L., Tafuro, S., Laugel, B., Glick, M., Boulter, J. M., Jakobsen, B. K., Price, D. A., and Sewell, A. K. (2003). The CD8 T cell coreceptor exhibits disproportionate biological activity at extremely low binding affinities. J Biol Chem 278, 24285-24293.

1) Glick, M., Price, D. A., Vuidepot, A. L., Andersen, T. B., Hutchinson, S. L., Laugel, B., Sewell, A. K., Boulter, J. M., Dunbar, P. R., Cerundolo, V., et al. (2002). Novel CD8+ T cell antagonists based on beta 2-microglobulin. J Biol Chem 277, 20840-20846.

¶ shared first authorship.