32) Bridgeman JS, Sewell AK, Miles JJ, Price DA, Cole DK. Structural and biophysical determinants of T-cell antigen recognition. Immunology. 2011 In press. Impact factor: 3.3.
31) Laugel B, Cole DK, Clement M, Wooldridge L, Price DA, Sewell AK. The multiple roles of the CD8 coreceptor in T cell biology: opportunities for the selective modulation of self-reactive cytotoxic T cells. Journal of Leukocyte Biology. 2011 Oct 7. [Epub ahead of print]. Impact factor: 4.6.
30) Agnew C, Borodina E, Zaccai NR, Conners R, Burton NM, Vicary JA, Cole DK, Antognozzi M, Virji M, Brady RL. Correlation of in situ mechanosensitive responses of the Moraxella catarrhalis adhesin UspA1 with fibronectin and receptor CEACAM1 binding. Proceedings of the National Acadamy of Science U S A. 2011 Sep 13;108(37):15174-8. Epub 2011 Aug 29. Impact factor: 9.8.
29) Clement M, Ladell K, Ekeruche J, Miles JJ, Edwards EJS, Dolton G, Schauenburg AJA, Cole DK, Lauder SN, Gallimore AM, Godkin AJ, Burrows SR, Price DA, Sewell AK, Wooldridge L. Anti-CD8 antibodies can trigger T-cellleffector function in the absence of TCR engagement and improve pMHCI tetramer staining. Journal of Immunology. 2011 Jul 15;187 (2):654-63. Impact factor: 5.8.
28) Miles KM, Miles JJ, Madura M, Sewell AK and Cole DK. Real time detection of peptide-MHC dissociation reveals that improvement of primary MHC-binding residues can have a minimal, or no effect on complex stability. Molecualr Immunology. 2011 Jan;48(4):728-32.
27) Cole DK, Miles JJ, Bulek A, Gostick E, Schauenburg AJA, Dolton G, Venturi V, Davenport MP, Tan MP, Burrows SR, Wooldridge L, Price DA, Rizkallah PJ and Sewell AK. Genetic and structural basis for selection of a ubiquitous T cell receptor deployed in Epstein-Barr virus infection. PLOS Pathogens. 2010 Nov 18;6(11):e1001198.
26) Cole DK, Edwards EJ, Wynn KK, Clement M, Miles JJ, Ladell K, Ekeruche J, Gostick E, Adams K, Skowera S, Peakman M, Wooldridge L, Price DA and Sewell AK. Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T-cell recognition. Journal of Immunology. 2010 Aug 15;185(4):2600-10.
25) Wooldridge L, Clement M, Lissina A, Edwards E, Hewitt RE, Gostick E, Cole DK, Debets R, Price DA and Sewell AK. MHC class I molecules with Superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs. Journal of Immunology. 2010 Apr 1;184(7):3357-66.
24) Borbulevych OY,. Piepenbrink KH, Gloor BE, Scott DR, Sommese RF, Cole DK, Sewell AK, and Baker BM. T cell receptor crossreactivity directed by antigen-dependent molecular motion in a peptide/MHC complex. Immunity. 2009 Dec 18;31(6):885-96.
23) Horlock C, Stott B, Dyson J, Ogg G, McPherson T, Jones L, Sewell A, Wooldridge L, Cole DK, Stebbing J, Savage P. ELISPOT and functional T cell analyses using HLA mono-specific target cells. Journal of Immunological Methods. 2009 Oct 31;350(1-2):150-60. Epub 2009 Sep 1.
22) Choudhuri K, Parker M, Milicic A, Cole DK, Shaw MK, Sewell AK, Stewart-Jones G, Dong T, Gould KG, and van der Merwe PA. Peptide-MHC dimensions control proximal kinase-phosphatase balance during T cell activation. Journal of Biological Chemistry. 2009 Sep 18;284(38):26096-105. Epub 2009 Jul 23.
21) Cole DK, Yuan F, Rizkallah PJ, Miles JJ, Gostick E, Price DA, Gao GF, Jakobsen BK, Sewell AK. Germline-governed recognition of a cancer epitope by an immunodominant human T-cell receptor. Journal of Biological Chemistry. 2009 Oct 2;284(40):27281-9. Epub 2009 Jul 15.
20) Wooldridge L, Lissina A, Cole DK, van den Berg HA, Price DA andSewell AK. Tricks with Tetramers: How to get the most from multimeric peptide-MHC. Immunology. 2009 Feb; 126(2): 147-64.
19) Varela-Rohena A, Molloy PE, Dunn SM, Li Y, Suhoski MM, Carroll RG, Milicic A, Mahon T, Sutton DH, Laugel B, Moysey R, Cameron BJ, Vuidepot A, Purbhoo MA, Cole DK, Phillips RE, June CH, Jakobsen BK, Sewell AK, Riley JL. Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor. Nature Medicine. 2008 Dec;14(12):1390-5.
18) Melenhorst JJ, Scheinberg P, Chattopadhyay PK, Lissina A, Gostick E, Cole DK, Wooldridge L, van den Berg HA, Bornstein E, Hensel NF, Douek DC, Roederer M, Sewell AK, Barrett AJ, Price DA. Detection of low avidity CD8(+) T cell populations with coreceptor-enhanced peptide-major histocompatibility complex class I tetramers. Journal of Immunological Methods. 2008 Sep 30;338(1-2):31-9.
17) Cole DK, Dunn SM, Sami M, Boulter JM, Jakobsen BK, Sewell AK. T cell receptor engagement of peptide-major histocompatibility complex class I does not modify CD8 binding. Molecular Immunology. 2008 May;45(9):2700-9.
16) Laugel B, van den Berg HA, Gostick E, Cole DK, Wooldridge L, Boulter JM, Milicic A, Price DA, Sewell AK. Different T cell receptor affinity thresholds and CD8 coreceptor dependency govern cytotoxic T lymphocyte activation and tetramer binding properties. Journal of Biological Chemistry. 2007: 282(33): 23799-810.
15) Cole DK, Pumphrey NJ, Boulter JM, Sami M, Bell JI, Gostick E, Price DA, Gao GF, Sewell AK, Jakobsen BK. Human TCR-Binding Affinity is Governed by MHC Class Restriction. Journal of Immunology. 2007: 178(9): 5727-34.
14) Gostick E, Cole DK, Hutchinson SL, Wooldridge L, Tafuro S, Laugel B, Lissina A, Oxenius A, Boulter JM, Price DA, Sewell AK. Functional and biophysical characterization of an HLA A*6801-restricted HIV-specific T cell receptor. European Journal of Immunology. 2007: 37(2): 479-86.
13) Cole DK, Rizkallah PJ, Boulter JM, Sami M, Vuidepot AL, Glick M, Gao F, Bell JI, Jakobsen BK, Gao GF. Computational design and crystal structure of an enhanced affinity mutant human CD8 alpha/alpha co-receptor. Proteins. 2007: 67(1): 65-74.
12) Cole DK, Rizkallah PJ, Gao F, Watson, NI, Boulter JM., Bell JI., Sami M, Gao GF, Jakobsen BK. Crystal structure of HLA-A*2402 complexed with a telomerase peptide. European Journal of. Immunology. 2006: 36: 170-9.
11) Cole DK, Rizkallah PJ, Boulter JM., Sami M, Vuidepot AL, Glick M, Gao F, Bell JI., Jakobsen BK, Gao GF. Crystallisation and preliminary X-ray structural studies of a high affinity CD8alpha/alpha co-receptor to pMHC. ACTA F. 2005, F61, 0-0.
10) Wang HW, Cole D, Jiang WZ, Jin HT, Fu N, Chen ZL, Jin NY. Engineering and functional evaluation of a single-chain antibody against HIV-1 external glycoprotein gp120. Clinical and Experimental Immunology. 2005: 141: 72-80.
9) Cole DK, Gao GF. CD8: Adhesion molecule, co-receptor and immuno-modulator. Cellular & Molecular Immunology. 2004: 2: 81-88.
8) Xu Y, Zhu J, Liu Y, Lou Z, Yuan F, Liu Y, Cole DK, Ni L, Su N, Qin L, Li X, Bai Z, Bell JI, Pang H, Tien P, Gao GF, Rao Z. Characterization of the heptad repeat regions, HR1 and HR2, and design of a fusion core structure model of the spike protein from severe acute respiratory syndrome (SARS) coronavirus. Biochemistry. 2004: 43: 14064-71.
7) Xu Y, Cole DK, Lou Z, Liu Y, Qin L, Li X, Bai Z, Yuan F, Rao Z, Gao GF. Construct design, biophysical, and biochemical characterization of the fusion core from mouse hepatitis virus (a coronavirus) spike protein. Protein Expression and Purification. 2004: 38: 116-22.
6) Wang X, Xu Y, Cole DK, Lou Z, Liu Y, Rao Z, Wang M, Gao GF. Biochemical, biophysical and preliminary X-ray crystallographic analyses of the fusion core of Sendai virus F protein. Acta Crystallography D Biological Crystallography. 2004: 60: 1632-5.
5) Zhou M, Xu Y, Lou Z, Cole DK, Li X, Liu Y, Tien P, Rao Z, Gao GF. Complex assembly, crystallization and preliminary X-ray crystallographic studies of MHC H-2Kd complexed with an HBV-core nonapeptide. Acta Crystallography D Biological Crystallography. 2004: 60: 1473-5.
4) Yan H, Xiao G, Zhang J, Hu Y, Yuan F, Cole DK, Zheng C, Gao GF. SARS coronavirus induces apoptosis in Vero E6 cells. Journal of Medical Virology. 2004: 73: 323-31.
3) Xu Y, Lou Z, Liu Y, Cole DK, Su N, Qin L, Li X, Bai Z, Rao Z, Gao GF. Crystallization and preliminary crystallographic analysis of the fusion core from two new zoonotic paramyxoviruses, Nipah virus and Hendra virus. Acta Crystallography D Biological Crystallography. 2004: 60: 1161-4.
2) Zhu J, Xiao G, Xu Y, Yuan F, Zheng C, Liu Y, Yan H, Cole DK, Bell JI, Rao Z, Tien P, Gao GF. Following the rule: formation of the 6-helix bundle of the fusion core from severe acute respiratory syndrome coronavirus spike protein and identification of potent peptide inhibitors. Biochemical and Biophysical Research Communications. 2004: 18: 283-8.
1) Xu Y, Gao S, Cole DK, Zhu J, Su N, Wang H, Gao GF, Rao Z. Basis for fusion inhibition by peptides: analysis of the heptad repeat regions of the fusion proteins from Nipah and Hendra viruses, newly emergent zoonotic paramyxoviruses. Biochemical and Biophysical Research Communications. 2004: 315: 664-70.