Scheinberg P, Melenhorst JJ, Brenchley JM, Hill BJ, Hensel NF, Chattopadhyay PK, Roederer M, Picker LJ, Price DA, Barrett AJ, Douek DC (2009). The transfer of adaptive immunity to cytomegalovirus (CMV) during hematopoietic stem cell transplantation is dependent on the specificity and phenotype of CMV-specific T cells in the donor. Blood (e-pub ahead of print).
Honda M, Wang R, Kong W-P, Kanekiyo M, Akahata W, Xu L, Matsuo K, Natarajan K, Robinson H, Asher TE, Price DA, Douek DC, Margulies DH, Nabel GJ (2009). Different vaccine vectors delivering the same antigen elicit CD8+ T cell responses with distinct clonotype and epitope specificity. J. Immunol. 183: 2425-2434.
Cole DK*, Yuan F*, Rizkallah PJ*, Miles JJ, Gostick E, Price DA, Gao GF, Jakobsen BK, Sewell AK (2009). Germ line-governed recognition of a cancer epitope by an immunodominant human T-cell receptor. J. Biol. Chem. 284: 27281-27289.
Petrovas C, Chaon B, Ambrozak DR, Price DA, Melenhorst JJ, Hill BJ, Geldmacher C, Casazza JP, Chattopadhyay PK, Roederer M, Douek DC, Mueller YM, Jacobson JM, Kulkarni V, Felber BK, Pavlakis GN, Katsikis PD, Koup RA (2009). Differential association of programmed death-1 and CD57 with ex vivo survival of CD8+ T cells in HIV infection. J. Immunol. 183: 1120-1132.
Geldmacher C, Metzler IS, Tovanabutra S, Asher TE, Gostick E, Ambrozak DR, Petrovas C, Schuetz A, Ngwenyama N, Kijak G, Maboko L, Hoelscher M, McCutchan F, Price DA, Douek DC, Koup RA (2009). Minor viral and host genetic polymorphisms can dramatically impact the biologic outcome of an epitope-specific CD8 T-cell response. Blood 114: 1553-1562.
Bimber BN, Burwitz BJ, O’Connor S, Detmer A, Gostick E, Lank SM, Price DA, Hughes A, O’Connor D (2009). Ultradeep pyrosequencing detects complex patterns of CD8+ T-lymphocyte escape in simian immunodeficiency virus-infected macaques. J. Virol. 83: 8247-8253.
Greenaway HY, Kurniawan M, Price DA, Douek DC, Davenport MP, Venturi V (2009). Extraction and characterization of the rhesus macaque T-cell receptor b-chain genes. Immunol. Cell Biol. 87: 546-553.
Almeida JR, Sauce D, Price DA, Papagno L, Shin SY, Moris A, Larsen M, Pancino G, Douek DC, Autran B, Saez-Cirion A, Appay V (2009). Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activity. Blood 113: 6351-6360.
Price DA, Asher TE, Wilson NA, Nason MC, Brenchley JM, Metzler IS, Venturi V, Gostick E, Chattopadhyay PK, Roederer M, Davenport MP, Watkins DI, Douek DC (2009). Public clonotype usage identifies protective Gag-specific CD8+ T cell responses in SIV infection. J. Exp. Med. 206: 923-936.
Nakamoto N, Cho H, Shaked A, Olthoff K, Valiga ME, Kaminski M, Gostick E, Price DA, Freeman GJ, Wherry EJ, Chang K-M (2009). Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1/CTLA-4 blockade. PLoS Pathog. 5: e1000313.
Melenhorst JJ, Scheinberg P, Chattopadhyay PK, Gostick E, Ladell K, Roederer M, Hensel NF, Douek DC, Barrett AJ, Price DA (2009). High avidity myeloid leukemia-associated antigen-specific CD8+ T cells preferentially reside in the bone marrow. Blood 113: 2238-2244.
Lissina A, Ladell K, Skowera A, Clement M, Edwards E, Seggewiss R, van den Berg HA, Gostick E, Gallagher K, Jones E, Melenhorst JJ, Godkin AJ, Peakman M, Price DA, Sewell AK, Wooldridge L (2009). Protein kinase inhibitors substantially improve the physical detection of T-cells with peptide-MHC tetramers. J. Immunol. Methods 340: 11-24.
Wooldridge L, Lissina A, Cole DK, van den Berg HA, Price DA, Sewell AK (2009). Tricks with tetramers: how to get the most from multimeric peptide-MHC. Immunology 126:147-164.
Chattopadhyay PK, Betts MR, Price DA, Gostick E, Horton H, Roederer M, de Rosa SC (2009). The cytolytic enzymes granzyme A, granzyme B, and perforin: expression patterns, cell distribution, and their relationship to cell maturity and bright CD57 expression. J. Leukoc. Biol. 85: 88-97.
Venturi V, Chin HY, Asher TE, Ladell K, Scheinberg P, Bornstein E, van Bockel D, Kelleher AD, Douek DC, Price DA, Davenport MP (2008). TCR b-chain sharing in human CD8+ T cell responses to cytomegalovirus and EBV. J. Immunol. 181: 7853-7862.
Reynolds MR, Weiler AM, Weisgrau KL, Piaskowski SM, Furlott JR, Weinfurter JT, Kaizu M, Soma T, Leon EJ, MacNair C, Leaman DP, Zwick MB, Gostick E, Musani SK, Price DA, Friedrich TC, Rakasz EG, Wilson NA, McDermott AB, Boyle R, Allison DB, Burton DR, Koff WC, Watkins DI (2008). Macaques vaccinated with live-attenuated SIV control replication of heterologous virus. J. Exp. Med. 205: 2537-2550.
Chattopadhyay PK*, Melenhorst JJ*, Ladell K, Gostick E, Scheinberg P, Barrett AJ, Wooldridge L, Roederer M, Sewell AK, Price DA (2008). Techniques to improve the direct ex vivo detection of low frequency antigen-specific CD8+ T cells with peptide-major histocompatibility complex class I tetramers. Cytometry A 73: 1001-1009.
Brenchley JM, Paiardini M, Knox KS, Asher AI, Cervasi B, Asher TE, Scheinberg P, Price DA, Hage CA, Kholi LM, Khoruts A, Frank I, Else J, Schacker T, Silvestri G, Douek DC (2008). Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections. Blood 112: 2826-2835.
Seggewiss R, Price DA, Purbhoo MA (2008). Immunomodulatory effects of imatinib and second-generation tyrosine kinase inhibitors on T cells and dendritic cells: an update. Cytotherapy 10: 633-641.
Venturi V, Chin HY, Price DA, Douek DC, Davenport MP (2008). The role of production frequency in the sharing of simian immunodeficiency virus-specific CD8+ TCRs between macaques. J. Immunol. 181: 2597-2609.
Melenhorst JJ, Scheinberg P, Chattopadhyay PK, Lissina A, Gostick E, Cole DK, Wooldridge L, van den Berg HA, Bornstein E, Hensel NF, Douek DC, Roederer M, Sewell AK, Barrett AJ, Price DA (2008). Detection of low avidity CD8+ T cell populations with coreceptor-enhanced peptide-major histocompatibility complex class I tetramers. J. Immunol. Methods 338: 31-39.
Hestvik ALK, Skorstad G, Price DA, Vartdal F, Holmoy T (2008). Multiple sclerosis: glatiramer acetate induces anti-inflammatory T cells in the cerebrospinal fluid. Mult. Scler. 14: 749-758.
Nakamoto N, Kaplan DE, Coleclough J, Li Y, Valiga ME, Kaminski M, Shaked A, Olthoff K, Gostick E, Price DA, Freeman GJ, Wherry EJ, Chang K-M (2008). Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization. Gastroenterology 134: 1927-1937.
Appay V, Douek DC, Price DA (2008). CD8+ T cell efficacy in vaccination and disease. Nature Med. 14: 623-628.
Smith MZ, Asher TE, Venturi V, Davenport MP, Douek DC, Price DA, Kent SJ (2008). Limited maintenance of vaccine-induced simian immunodeficiency virus-specific CD8 T-cell receptor clonotypes after virus challenge. J. Virol. 82: 7357-7368.
Ebinuma H, Nakamoto N, Li Y, Price DA, Gostick E, Levine BL, Tobias J, Kwok WW, Chang K-M (2008). Identification and in vitro expansion of functional antigen-specific CD25+ FoxP3+ regulatory T cells in hepatitis C virus infection. J. Virol. 82: 5043-5053.
Melenhorst JJ, Lay MDH, Price DA, Adams SD, Zeilah J, Sosa E, Hensel NF, Follmann D, Douek DC, Davenport MP, Barrett AJ (2008). Contribution of TCR-b locus and HLA to the shape of the mature human Vb repertoire. J. Immunol. 180: 6484-6489.
Brenchley JM, Knox KS, Asher AI, Price DA, Kohli LM, Gostick E, Hill BJ, Hage CA, Brahmi Z, Khoruts A, Twigg HL, Schacker TW, Douek DC (2008). High frequencies of polyfunctional HIV-specific T cells are associated with preservation of mucosal CD4 T cells in bronchoalveolar lavage. Mucosal Immunol. 1: 49-58.
Weichsel R, Dix C, Wooldridge L, Clement M, Fenton-May A, Sewell AK, Zezula J, Greiner E, Gostick E, Price DA, Einsele H, Seggewiss R (2008). Profound inhibition of antigen-specific T-cell effector functions by dasatinib. Clin. Cancer Res. 14: 2484-2491.
Mielke S, Nunes R, Rezvani K, Fellowes VS, Venne A, Solomon SR, Fan Y, Gostick E, Price DA, Scotto C, Read EJ, Barrett AJ (2008). A clinical-scale selective allodepletion approach for the treatment of HLA-mismatched and matched donor-recipient pairs using expanded T lymphocytes as antigen-presenting cells and a TH9402-based photodepletion technique. Blood 111: 4392-4402.
Melenhorst JJ, Scheinberg P, Lu J, Ambrozak DR, Sosa E, Zhao L, Hensel NF, Savani BN, Douek DC, Price DA, Barrett AJ (2008). Regulatory T-cell depletion does not prevent emergence of new CD25+ FOXP3+ lymphocytes after antigen stimulation in culture. Cytotherapy 10: 152-164.
Venturi V, Price DA, Douek DC, Davenport MP (2008). The molecular basis for public T-cell responses? Nature Rev. Immunol. 8: 231-238.
Daucher M, Price DA, Brenchley JM, Lamoreaux L, Metcalf JA, Rehm C, Nies-Kraske E, Urban E, Yoder C, Rock D, Gumkowski J, Betts MR, Dybul MR, Douek DC (2008). Virological outcome after structured interruption of antiretroviral therapy for human immunodeficiency virus infection is associated with the functional profile of virus-specific CD8+ T cells. J. Virol. 82: 4102-4114.
Rehr M, Cahenzli J, Haas A, Price DA, Gostick E, Huber M, Karrer U, Oxenius A (2008). Emergence of polyfunctional CD8+ T cells after prolonged suppression of human immunodeficiency virus replication by antiretroviral therapy. J. Virol. 82: 3391-3404.
Price DA*, Bitmansour AD*, Edgar JB, Walker JM, Axthelm MK, Douek DC, Picker LJ (2008). Induction and evolution of cytomegalovirus-specific CD4+ T cell clonotypes in rhesus macaques. J. Immunol. 180: 269-280.
Maness NJ, Valentine LE, May GE, Reed J, Piaskowski SM, Soma T, Furlott J, Rakasz EG, Friedrich TC, Price DA, Gostick E, Hughes AL, Sidney J, Sette A, Wilson NA, Watkins DI (2007). AIDS virus-specific CD8+ T lymphocytes against an immunodominant cryptic epitope select for viral escape. J. Exp. Med. 204: 2505-2512.
Loffredo JT, Friedrich TC, Leon EJ, Stephany JJ, Rodrigues DS, Spencer SP, Bean AT, Beal DR, Burwitz BJ, Rudersdorf RA, Wallace LT, Piaskowski SM, May GE, Sidney J, Gostick E, Wilson NA, Price DA, Kallas EG, Piontkivska H, Hughes AL, Sette A, Watkins DI (2007). CD8+ T cells from SIV elite controller macaques recognize Mamu-B*08-bound epitopes and select for widespread viral variation. PLoS ONE 2: e1152.
Beveridge NER, Price DA, Casazza JP, Pathan AA, Sander CR, Asher TE, Ambrozak DR, Precopio ML, Scheinberg P, Alder NC, Roederer M, Koup RA, Douek DC, Hill AVS, McShane H (2007). Immunisation with BCG and recombinant MVA85A induces long-lasting, polyfunctional Mycobacterium tuberculosis-specific CD4+ memory T lymphocyte populations. Eur. J. Immunol. 37: 3089-3100.
Almeida JR, Price DA, Papagno L, Arkoub ZA, Sauce D, Bornstein E, Asher TE, Samri A, Schnuriger A, Theodorou I, Costagliola D, Rouzioux C, Agut H, Marcelin A-G, Douek D, Autran B, Appay V (2007). Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover. J. Exp. Med. 204: 2473-2485.
Yuan F, Georgiou T, Hillon T, Gostick E, Price DA, Sewell AK, Moysey R, Gavarret J, Vuidepot A, Sami M, Bell JI, Gao GF, Rizkallah PJ, Jakobsen BK (2007). Crystallization and preliminary X-ray structural studies of a Melan-A pMHC-TCR complex. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 63: 758-760.
van Bockel D, Price DA, Asher TE, Venturi V, Suzuki K, Warton K, Davenport MP, Cooper DA, Douek DC, Kelleher AD (2007). Validation of RNA-based molecular clonotype analysis for virus-specific CD8+ T-cells in formaldehyde-fixed specimens isolated from peripheral blood. J. Immunol. Methods 326: 127-138.
Laugel B, van den Berg HA, Gostick E, Cole DK, Wooldridge L, Boulter J, Milicic A, Price DA, Sewell AK (2007). Different T cell receptor affinity thresholds and CD8 coreceptor dependence govern cytotoxic T lymphocyte activation and tetramer binding properties. J. Biol. Chem. 282: 23799-23810.
Rezvani K, Yong ASM, Savani BN, Mielke S, Keyvanfar K, Gostick E, Price DA, Douek DC, Barrett AJ (2007). Graft-versus-leukemia effects associated with detectable Wilm’s tumor-1-specific T lymphocytes after allogeneic stem-cell transplantation for acute lymphoblastic leukemia. Blood 110: 1924-1932.
Purbhoo MA, Li Y, Sutton DH, Brewer JE, Gostick E, Bossi G, Laugel B, Moysey R, Baston E, Liddy N, Cameron B, Bennett AD, Ashfield R, Milicic A, Price DA, Classon BJ, Sewell AK, Jakobsen BK (2007). The HLA A*0201-restricted hTERT540-548 peptide is not detected on tumor cells by a CTL clone or a high-affinity T-cell receptor. Mol. Cancer Ther. 6: 2081-2091.
Petrovas C, Price DA, Mattapallil J, Ambrozak DR, Geldmacher C, Cecchinato V, Vaccari M, Tryniszewska E, Gostick E, Roederer M, Douek DC, Morgan SH, Davis SJ, Franchini G, Koup RA (2007). SIV-specific CD8+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection. Blood 110: 928-936.
Schaubert KL, Price DA, Frahm N, Li J, Ng HL, Joseph A, Paul E, Majumder B, Ayyavoo V, Gostick E, Adams S, Marincola FM, Sewell AK, Altfeld M, Brenchley JM, Douek DC, Yang OO, Brander C, Goldstein H, Kan-Mitchell J (2007). Availability of a diversely avid CD8+ T cell repertoire specific for the subdominant HLA-A2-restricted HIV-1 Gag p2419-27 epitope. J. Immunol. 178: 7756-7766.
Precopio ML, Betts MR, Parrino J, Price DA, Gostick E, Ambrozak DR, Asher TE, Douek DC, Harari A, Pantaleo G, Bailer R, Graham BS, Roederer M, Koup RA (2007). Immunization with vaccinia virus induces polyfunctional and phenotypically distinctive CD8+ T cell responses. J. Exp. Med. 204: 1405-1416.
Davenport MP, Price DA, McMichael AJ (2007). The T cell repertoire in infection and vaccination: implications for control of persistent viruses. Curr. Opin. Immunol. 19: 294-300.
Rezvani K, Price DA, Brenchley JM, Kilical Y, Gostick E, Sconocchia G, Hansmann K, Kurlander R, Douek DC, Barrett AJ (2007). Transfer of PR1-specific T-cell clones from donor to recipient by stem cell transplantation and association with GvL activity. Cytotherapy 9: 245-251.
Wooldridge L, Lissina A, Vernazza J, Gostick E, Laugel B, Hutchinson SL, Mirza F, Dunbar PR, Boulter JM, Glick M, Cerundolo V, van den Berg HA, Price DA, Sewell AK (2007). Enhanced immunogenicity of CTL antigens through mutation of the CD8 binding MHC class I invariant region. Eur. J. Immunol. 37: 1323-1333.
Cole DK, Pumphrey NJ, Boulter JM, Sami M, Bell JI, Gostick E, Price DA, Gao GF, Sewell AK, Jakobsen BK (2007). Human TCR-binding affinity is governed by MHC class restriction. J. Immunol. 178: 5727-5734.
Laugel B, Price DA, Milicic A, Sewell AK (2007). CD8 exerts differential effects on the deployment of cytotoxic T lymphocyte effector functions. Eur. J. Immunol. 37: 905-913.
Scheinberg P, Melenhorst JJ, Hill BJ, Keyvanfar K, Barrett AJ, Price DA, Douek DC (2007). The clonal composition of human CD4+CD25+Foxp3+ cells determined by a comprehensive DNA-based multiplex PCR for TCRB gene rearrangements. J. Immunol. Methods 321: 107-120.
Hryniewicz A*, Price DA*, Moniuszko M*, Boasso A, Edghill-Spano Y, West SM, Venzon D, Vaccari M, Tsai W-P, Tryniszewska E, Nacsa J, Villinger F, Ansari AA, Trindade CJ, Morre M, Brooks D, Arlen P, Brown HJ, Kitchen CMR, Zack JA, Douek DC, Shearer GM, Lewis MG, Koup RA, Franchini G (2007). Interleukin-15 but not interleukin-7 abrogates vaccine-induced decrease in virus level in simian immunodeficiency virusmac251-infected macaques. J. Immunol. 178: 3492-3504.
Gostick E, Cole DK, Hutchinson SL, Wooldridge L, Tafuro S, Laugel B, Lissina A, Oxenius A, Boulter JM, Price DA, Sewell AK (2007). Functional and biophysical characterization of an HLA A*6801-restricted HIV-specific T cell receptor. Eur. J. Immunol. 37: 479-486.
Brenchley JM, Price DA, Schacker TW, Asher TE, Silvestri G, Rao S, Kazzaz Z, Bornstein E, Lambotte O, Altmann D, Blazar BR, Rodriguez B, Teixeira-Johnson L, Landay A, Martin JN, Hecht FM, Picker LJ, Lederman MM, Deeks SG, Douek DC (2006). Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nature Med. 12: 1365-1371.
Casazza JP, Betts MR, Price DA, Precopio ML, Ruff LE, Brenchley JM, Hill BJ, Roederer M, Douek DC, Koup RA (2006). Acquisition of direct antiviral effector functions by CMV-specific CD4+ T lymphocytes with cellular maturation. J. Exp. Med. 203: 2865-2877.
Venturi V, Kedzierska K, Price DA, Doherty PC, Douek DC, Turner SJ, Davenport MP (2006). Sharing of T cell receptors in antigen-specific responses is driven by convergent recombination. Proc. Natl. Acad. Sci. USA 103: 18691-18696.
Leslie A, Price DA, Mkhize P, Bishop K, Rathod A, Day C, Crawford H, Honeyborne I, Asher TE, Luzzi G, Edwards A, Rosseau CM, Mullins JI, Tudor-Williams G, Novelli V, Brander C, Douek DC, Kiepiela P, Walker BD, Goulder PJR (2006). Differential selection pressure exerted on HIV by CTL targeting identical epitopes but restricted by distinct HLA alleles from the same HLA supertype. J. Immunol. 177: 4699-4708.
Petrovas C, Casazza JP, Brenchley JM, Price DA, Gostick E, Adams WC, Precopio ML, Schacker T, Roederer M, Douek DC, Koup RA (2006). PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection. J. Exp. Med. 203: 2281-2292.
Chattopadhyay PK, Price DA, Harper TF, Betts MR, Yu J, Gostick E, Perfetto SP, Goepfert P, Koup RA, De Rosa SC, Bruchez MP, Roederer M (2006). Quantum dot semiconductor nanocrystals for immunophenotyping by polychromatic flow cytometry. Nature Med. 12: 972-977.
Brenchley JM, Ruff LE, Casazza JP, Koup RA, Price DA, Douek DC (2006). Preferential infection shortens the life span of human immunodeficiency virus-specific CD4+ T cells in vivo. J. Virol. 80: 6801-6809.
Wooldridge L, Scriba TJ, Milicic A, Laugel B, Gostick E, Price DA, Phillips RE, Sewell AK (2006). Anti-coreceptor antibodies profoundly affect staining with peptide-MHC class I and class II tetramers. Eur. J. Immunol. 36: 1847-1855.
Laugel B, Price DA, Sewell AK (2006). On the path to TCR-directed therapeutics. Nature Biotechnol. 24: 615-616.
Scheinberg P, Price DA, Ambrozak DR, Barrett AJ, Douek DC (2006). Alloreactive T cell clonotype recruitment in a mixed lymphocyte reaction: implications for graft engineering. Exp. Hematol. 34: 788-795.
Kan-Mitchell J, Bajcz M, Schaubert KL, Price DA, Brenchley JM, Asher TE, Douek DC, Ng HL, Yang OO, Rinaldo CR, Benito JM, Bisikirska B, Hegde R, Marincola FM, Boggiano C, Wilson D, Abrams J, Blondelle SE, Wilson DB (2006). Degeneracy and repertoire of the human HIV-1 Gag p1777-85 CTL response. J. Immunol. 176: 6690-6701.
Brenchley JM, Price DA, Douek DC (2006). HIV disease: fallout from a mucosal catastrophe? Nature Immunol. 7: 235-239.
Rezvani K, Brenchley JM, Price DA, Kilical Y, Gostick E, Sewell AK, Li J, Mielke S, Douek DC, Barrett AJ (2005). T-cell responses directed against multiple HLA-A*0201-restricted epitopes derived from Wilms’ tumor 1 protein in patients with leukemia and healthy donors: identification, quantification, and characterization. Clin. Cancer Res. 11: 8799-8807.
Price DA, Brenchley JM, Ruff LE, Betts MR, Hill BJ, Roederer M, Koup RA, Migueles SA, Gostick E, Wooldridge L, Sewell AK, Connors M, Douek DC (2005). Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA viruses. J. Exp. Med. 202: 1349-1361.
Milicic A, Price DA, Zimbwa P, Booth BL, Brown HL, Easterbrook PJ, Olsen K, Robinson N, Gileadi U, Sewell AK, Cerundolo V, Phillips RE (2005). CD8+ T cell epitope-flanking mutations disrupt proteasomal processing of HIV-1 Nef. J. Immunol. 175: 4618-4626.
Wooldridge L, van den Berg H, Glick M, Gostick E, Laugel B, Hutchinson SL, Milicic A, Brenchley JM, Douek DC, Price DA, Sewell AK (2005). Interaction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surface. J. Biol. Chem. 280: 27491-27501.
Joos B, Trkola A, Fischer M, Kuster H, Rusert P, Leemann C, Böni J, Oxenius A, Price DA, Phillips RE, Wong JK, Hirschel B, Weber R, Günthard HF & The Swiss HIV Cohort Study (2005). Low human immunodeficiency virus envelope diversity correlates with low in vitro replication capacity and predicts spontaneous control of plasma viremia after treatment interruptions. J. Virol. 79: 9026-9037.
Fujiwara H, Melenhorst JJ, El Ouriaghli F, Kajigaya S, Grübe M, Sconocchia G, Rezvani K, Price DA, Hensel NF, Douek DC, Barrett AJ (2005). In vitro induction of myeloid leukemia-specific CD4 and CD8 T cells by CD40 ligand-activated B cells gene modified to express primary granule proteins. Clin. Cancer Res. 11: 4495-4503.
Betts MR, Exley B, Price DA, Bansal A, Camacho ZT, Teaberry V, West SM, Ambrozak DR, Tomaras G, Roederer M, Kilby JM, Tartaglia J, Belshe R, Gao F, Douek DC, Weinhold KJ, Koup RA, Goepfert P, Ferrari G (2005). Characterization of functional and phenotypic changes in anti-Gag vaccine-induced T cell responses and their role in protection after HIV-1 infection. Proc. Natl. Acad. Sci. USA 102: 4512-4517.
Seggewiss R, Lore K, Greiner E, Magnusson MK, Price DA, Douek DC, Dunbar CE, Wiestner A (2005). Imatinib inhibits T-cell receptor-mediated T-cell proliferation and activation in a dose-dependent manner. Blood 105: 2473-2479.
Casazza JP, Betts MR, Hill BJ, Brenchley JM, Price DA, Douek DC, Koup RA (2005). Immunologic pressure within class I-restricted cognate human immunodeficiency virus epitopes during highly active antiretroviral therapy J. Virol. 79: 3653-3663.
Ellmerich S, Mycko M, Takacs K, Waldner H, Wahid FN, Boyton RJ, King RHM, Smith PA, Amor S, Herlihy AH, Hewitt RE, Jutton M, Price DA, Hafler DA, Kuchroo VK, Altmann DM (2005). High incidence of spontaneous disease in an HLA-DR15 and TCR transgenic multiple sclerosis model. J. Immunol. 174: 1938-1946.
Laugel B, Boulter JM, Lissin N, Vuidepot A, Li Y, Gostick E, Crotty LE, Douek DC, Hemelaar J, Price DA, Jakobsen BK, Sewell AK (2005). Design of soluble recombinant T cell receptors for antigen targeting and T cell inhibition. J. Biol. Chem. 280: 1882-1892.
Hewitt RE, Lissina A, Green AE, Slay ES, Price DA, Sewell AK (2005). The bisphosphonate acute phase response: rapid and copious production of proinflammatory cytokines by peripheral blood gd T cells in response to aminobisphosphonates is inhibited by statins. Clin. Exp. Immunol. 139: 101-111.
Price DA, West SM, Betts MR, Ruff LE, Brenchley JM, Ambrozak DR, Edghill-Smith Y, Kuroda MJ, Bogdan D, Kunstman K, Letvin NL, Franchini G, Wolinsky SM, Koup RA, Douek DC (2004). T cell receptor recognition motifs govern immune escape patterns in acute SIV infection. Immunity 21: 793-803.
Brenchley JM, Schacker TW, Ruff LE, Price DA, Taylor JH, Beilman GJ, Nguyen PL, Khoruts A, Larson M, Haase AT, Douek DC (2004). CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract. J. Exp. Med. 200: 749-759.
Scherer A, Frater J, Oxenius A, Agudelo J, Price DA, Günthard HF, Barnardo M, Perrin L, Hirschel B, Phillips RE, McLean AR & The Swiss HIV Cohort Study (2004). Quantifiable cytotoxic T lymphocyte responses and HLA-related risk of progression to AIDS. Proc. Natl. Acad. Sci. USA 101: 12266-12270.
Oxenius A, Price DA, Trkola A, Edwards C, Gostick E, Zhang H-T, Easterbrook PJ, Tun T, Johnson A, Waters A, Holmes EC, Phillips RE (2004). Loss of viral control in early HIV-1 infection is temporally associated with sequential escape from CD8+ T cell responses and decrease in HIV-1-specific CD4+ and CD8+ T cell frequencies. J. Infect. Dis. 190: 713-721.
Crawford MP, Yan SX, Ortega SB, Mehta RS, Hewitt RE, Price DA, Stastny P, Douek DC, Koup RA, Racke MK, Karandikar NJ (2004). High prevalence of autoreactive, neuroantigen-specific CD8+ T cells in multiple sclerosis revealed by novel flow cytometric assay. Blood 103: 4222-4231.
Green AE, Lissina A, Hutchinson SL, Hewitt RE, Temple B, James D, Boulter JM, Price DA, Sewell AK (2004). Recognition of nonpeptide antigens by human Vg9Vd2 T cells requires contact with cells of human origin. Clin. Exp. Immunol. 136: 472-482.
Betts MR, Price DA, Brenchley JM, Lore K, Guenaga FJ, Smed-Sorensen A, Ambrozak DR, Migueles SA, Connors M, Roederer M, Douek DC, Koup RA (2004). The functional profile of primary human antiviral CD8+ T cell effector activity is dictated by cognate peptide concentration. J. Immunol. 172: 6407-6417.
Fujiwara H, El Ouriaghli F, Grübe M, Price DA, Rezvani K, Gostick E, Sconocchia G, Melenhorst J, Hensel N, Douek DC, Barrett AJ (2004). Identification and in vitro expansion of CD4+ and CD8+ T cells specific for human neutrophil elastase. Blood 103: 3076-3083.
Oxenius A, Price DA, Hersberger M, Schlaepfer E, Weber R, Weber M, Kündig TM, Böni J, Joller H, Phillips RE, Flepp M, Opravil M, Speck RF (2004). HIV-specific cellular immune response is inversely correlated with disease progression as defined by decline of CD4+ T cells in relation to HIV RNA load. J. Infect. Dis. 189: 1199-1208.
Brenchley JM, Hill BJ, Ambrozak DR, Price DA, Guenaga FJ, Casazza JP, Kuruppu J, Yazdani J, Migueles SA, Connors M, Roederer M, Douek DC, Koup RA (2004). T-cell subsets that harbor human immunodeficiency virus (HIV) in vivo: implications for HIV pathogenesis. J. Virol. 78: 1160-1168.
Wooldridge L, Hutchinson SL, Choi EM, Lissina A, Jones E, Mirza F, Dunbar PR, Price DA, Cerundolo V, Sewell AK (2003). Anti-CD8 antibodies can inhibit or enhance peptide-MHC class I (pMHCI) multimer binding: this is paralleled by their effects on CTL activation and occurs in the absence of an interaction between pMHCI and CD8 on the cell surface. J. Immunol. 171: 6650-6660.
Brookes RH, Pathan AA, McShane H, Hensmann M, Price DA, Hill AVS (2003). CD8+ T cell-mediated suppression of intracellular Mycobacterium tuberculosis growth in activated human macrophages. Eur. J. Immunol. 33: 3293-3302.
Betts MR, Brenchley JM, Price DA, De Rosa SC, Douek DC, Roederer M, Koup RA (2003). Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation. J. Immunol. Methods 281: 65-78.
Rezvani K, Grübe M, Brenchley JM, Sconocchia G, Fujiwara H, Price DA, Gostick E, Yamada K, Melenhorst J, Childs R, Hensel N, Douek DC, Barrett AJ (2003). Functional leukemia-associated antigen-specific memory CD8+ T cells exist in healthy individuals and in patients with chronic myelogenous leukemia before and after stem cell transplantation. Blood 102: 2892-2900.
Hutchinson SL, Wooldridge L, Tafuro S, Laugel B, Glick M, Boulter JM, Jakobsen BK, Price DA, Sewell AK (2003). The CD8 T cell coreceptor exhibits disproportionate biological activity at extremely low binding affinities. J. Biol. Chem. 278: 24285-24293.
Fagard C, Oxenius A, Günthard H, Garcia F, Le Braz M, Mestre G, Battegay M, Furrer H, Vernazza P, Bernasconi E, Telenti A, Weber R, Leduc D, Yerly S, Price D, Dawson SJ, Klimkait T, Perneger TV, McLean A, Clotet B, Gatell JM, Perrin L, Plana M, Phillips R, Hirschel B (2003). A prospective trial of structured treatment interruptions in human immunodeficiency virus infection. Arch. Intern. Med. 163: 1220-1226.
Jones E, Price DA, Dahm-Vicker M, Cerundolo V, Klenerman P, Gallimore A (2003). The influence of macrophage inflammatory protein-1a on protective immunity mediated by antiviral cytotoxic T cells. Immunology 109: 68-75.
Price DA*, Scullard G*, Oxenius A*, Braganza R, Beddows SA, Kazmi S, Clarke JR, Johnson GE, Weber JN, Phillips RE (2003). Discordant outcomes following failure of antiretroviral therapy are associated with substantial differences in human immunodeficiency virus-specific cellular immunity. J. Virol. 77: 6041-6049.
Oxenius A, Price DA, Dawson SJ, Günthard HF, Fischer M, Perrin L, Ramirez E, Fagard C, Hirschel B, Scullard G, Weber JN, McLean AR, Phillips RE (2002). Residual HIV-specific CD4 and CD8 T cell frequencies after prolonged antiretroviral therapy reflect pretreatment plasma virus load. AIDS 16: 2317-2322.
Oxenius A, Sewell AK, Dawson SJ, Günthard HF, Fischer M, Gillespie GM, Rowland-Jones SL, Fagard C, Hirschel B, Phillips RE, Price DA (2002). Functional discrepancies in HIV-specific CD8+ T-lymphocyte populations are related to plasma virus load. J. Clin. Immunol. 22: 363-374.
Oxenius A, Price DA, Günthard HF, Dawson SJ, Fagard C, Perrin L, Fischer M, Weber R, Plana M, Garcia F, Hirschel B, McLean A, Phillips RE (2002). Stimulation of HIV-specific cellular immunity by structured treatment interruption fails to enhance viral control in chronic HIV infection. Proc. Natl. Acad. Sci. USA 99: 13747-13752.
Fidler S, Oxenius A, Brady M, Clarke J, Cropley I, Babiker A, Zhang H-T, Price D, Phillips R, Weber J (2002). Virological and immunological effects of short-course antiretroviral therapy in primary HIV infection. AIDS 16: 2049-2054.
Oxenius A, McLean AR, Fischer M, Price DA, Dawson SJ, Hafner R, Schneider C, Joller H, Hirschel B, Phillips RE, Weber R, Günthard HF (2002). Human immunodeficiency virus-specific CD8+ T-cell responses do not predict viral growth and clearance rates during structured intermittent antiretroviral therapy. J. Virol. 76: 10169-10176.
Price DA, Sewell AK (2002). Quantitative clonotypic analysis of antigen-specific T-cell responses. Trends Immunol. 23: 336-337.
Oxenius A, Jakobsen BK, Easterbrook PJ, Boulter JM, Tun T, Waters A, Agudelo J, Barnardo M, Phillips RE, Price DA (2002). Complete mapping of a novel HLA A*6801-restricted HIV-1 Tat epitope directly ex vivo with a rapid modified enzyme-linked immunospot assay. AIDS 16: 1285-1287.
Klenerman P, Tolfvenstam T, Price DA, Nixon DF, Broliden K, Oxenius A (2002). T lymphocyte responses against human parvovirus B19: small virus, big response. Pathol. Biol. 50: 317-325.
Glick M, Price DA, Vuidepot A-L, Andersen TB, Hutchinson SL, Laugel B, Sewell AK, Boulter JM, Dunbar PR, Cerundolo V, Oxenius A, Bell JI, Richards WG, Jakobsen BK (2002). Novel CD8+ T cell antagonists based on b2-microglobulin. J. Biol. Chem. 277: 20840-20846.
Douek DC*, Brenchley JM*, Betts MR, Ambrozak DA, Hill BJ, Okamoto Y, Casazza JP, Kuruppu J, Kunstman K, Wolinsky S, Grossman Z, Dybul M, Oxenius A, Price DA, Connors M, Koup RA (2002). HIV preferentially infects HIV-specific CD4+ T cells. Nature 417: 95-98.
Oxenius A, Price DA, Dawson SJ, Günthard HF, Fagard C, LeBraz M, Hirschel B, Perrin L, McLean AR, Phillips RE (2002). Modulation of HIV-specific immunity with novel therapeutic strategies. Labolife 11 (Nr 2): 9-10.
Sewell AK, Booth BL, Cerundolo V, Phillips RE, Price DA (2002). Differential processing of HLA A2-restricted HIV type 1 cytotoxic T lymphocyte epitopes. Viral Immunol. 15: 193-196.
Kelleher AD, Sewell AK, Price DA (2002). Dyslipidemia due to retroviral protease inhibitors. Nature Med. 8: 308-309.
Oxenius A, Fidler S, Brady M, Dawson SJ, Ruth K, Easterbrook PJ, Weber JN, Phillips RE, Price DA (2001). Variable fate of virus-specific CD4+ T cells during primary HIV-1 infection. Eur. J. Immunol. 31: 3782-3788.
Sewell AK, Price DA (2001). An inter-species difference in the CD8 coreceptor. Trends Immunol. 22: 595.
Purbhoo MA, Boulter JM, Price DA, Vuidepot A-L, Hourigan CS, Dunbar PR, Olsen K, Dawson SJ, Phillips RE, Jakobsen BK, Bell JI, Sewell AK (2001). The human CD8 coreceptor effects cytotoxic T cell activation and antigen sensitivity primarily by mediating complete phosphorylation of the T cell receptor z chain. J. Biol. Chem. 276: 32786-32792.
Korthals Altes H, Price DA, Jansen VAA (2001). Effector cytotoxic T lymphocyte numbers induced by vaccination should exceed levels in chronic infection for protection from HIV. Vaccine 20: 3-6.
Oxenius A, Yerly S, Ramirez E, Phillips RE, Price DA, Perrin L (2001). Distribution of functional HIV-specific CD8+ T lymphocytes between blood and secondary lymphoid organs after 8 to 18 months of antiretroviral therapy in acutely infected patients. AIDS 15: 1653-1656.
Phillips RE, Harcourt GC, Price DA (2001). CD4+ T cells: the great escape. Nature Med. 7: 777-778.
Kelleher AD, Booth BL, Sewell AK, Oxenius A, Cerundolo V, McMichael AJ, Phillips RE, Price DA (2001). Effects of retroviral protease inhibitors on proteasome function and processing of HIV-derived MHC class I-restricted cytotoxic T lymphocyte epitopes. AIDS Res. Hum. Retroviruses 17: 1063-1066.
Oxenius A, Günthard HF, Hirschel B, Fidler S, Weber JN, Easterbrook PJ, Bell JI, Phillips RE, Price DA (2001). Direct ex vivo analysis reveals distinct phenotypic patterns of HIV-specific CD8+ T lymphocyte activation in response to therapeutic manipulation of virus load. Eur. J. Immunol. 31: 1115-1121.
Karadimitris A, Gadola S, Altamirano M, Brown D, Woolfson A, Klenerman P, Chen J-L, Koezuka Y, Roberts IAG, Price DA, Dusheiko G, Milstein C, Fersht A, Luzzatto L, Cerundolo V (2001). Human CD1d-glycolipid tetramers generated by in vitro oxidative refolding chromatography. Proc. Natl. Acad. Sci. USA 98: 3294-3298.
Sewell AK, Price DA (2001). Dendritic cells and transmission of HIV-1. Trends Immunol. 22: 173-175.
Oxenius A*, Price DA*, Dawson SJ, Tun T, Easterbrook PJ, Phillips RE, Sewell AK (2001). Cross-staining of cytotoxic T lymphocyte populations with peptide-MHC class I multimers of natural HIV-1 variant antigens. AIDS 15: 121-122.
Tolfvenstam T, Oxenius A, Price DA, Shacklett BL, Spiegel HML, Hedman K, Norbeck O, Levi M, Olsen K, Kantzanou M, Nixon DF, Broliden K, Klenerman P (2001). Direct ex vivo measurement of CD8+ T lymphocyte responses to human parvovirus B19. J. Virol. 75: 540-543.
Price DA, Oxenius A (2000). Cellular immunity in primary HIV-1 infection: science, ART and the future. Immunol. News 7.4: 18-19.
Sewell AK, Price DA, Oxenius A, Kelleher AD, Phillips RE (2000). Cytotoxic T lymphocyte responses to human immunodeficiency virus: control and escape. Stem Cells 18: 230-244.
Oxenius A*, Price DA*, Easterbrook PJ*, O’Callaghan CA, Kelleher AD, Whelan JA, Sontag G, Sewell AK, Phillips RE (2000). Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes. Proc. Natl. Acad. Sci. USA 97: 3382-3387.
Phillips RE, Oxenius A, Price DA, Bangham CRM (2000). AIDS: the evolving story. Trends Microbiol. 8: 147-148.
Whelan JA*, Dunbar PR*, Price DA, Purbhoo MA, Lechner F, Ogg GS, Griffiths G, Phillips RE, Cerundolo V, Sewell AK (1999). Specificity of CTL interactions with peptide-MHC class I tetrameric complexes is temperature dependent. J. Immunol. 163: 4342-4348.
Price DA, O’Callaghan CA, Whelan JA, Easterbrook PJ, Phillips RE (1999). Cytotoxic T lymphocytes and viral evolution in primary HIV-1 infection. Clin. Sci. 97: 707-718.
Sewell AK, Price DA*, Teisserenc H*, Booth BL, Gileadi U, Flavin FM, Trowsdale J, Phillips RE, Cerundolo V (1999). Interferon-g exposes a cryptic cytotoxic T lymphocyte epitope in HIV-1 reverse transcriptase. J. Immunol. 162: 7075-7079.
Price DA, Klenerman P, Booth BL, Phillips RE, Sewell AK (1999). Cytotoxic T lymphocytes, chemokines and antiviral immunity. Immunol. Today 20: 212-216.
Sewell AK, Gerth UC*, Price DA*, Purbhoo MA, Boulter JM, Gao GF, Bell JI, Phillips RE, Jakobsen BK (1999). Antagonism of cytotoxic T lymphocyte activation by soluble CD8a/a homodimer. Nature Med. 5: 399-404.
Price DA, Meier U-C, Klenerman P, Purbhoo MA, Phillips RE, Sewell AK (1998). The influence of antigenic variation on cytotoxic T lymphocyte responses in HIV-1 infection. J. Mol. Med. 76: 699-708.
Lewis JW, Sewell A, Price D, Elliott T (1998). HLA-A*0201 presents TAP-dependent peptide epitopes to cytotoxic T lymphocytes in the absence of tapasin. Eur. J. Immunol. 28: 3214-3220.
Price DA, Sewell AK, Dong T, Tan R, Goulder PJR, Rowland-Jones SL, Phillips RE (1998). Antigen-specific release of b-chemokines by anti-HIV-1 cytotoxic T lymphocytes. Curr. Biol. 8: 355-358.
Goulder P, Price D, Nowak M, Rowland-Jones S, Phillips R, McMichael A (1997). Coevolution of human immunodeficiency virus and cytotoxic T lymphocyte responses. Immunol. Rev. 159: 17-29.
Sewell AK, Harcourt GC, Goulder PJR, Price DA, Phillips RE (1997). Antagonism of cytotoxic T lymphocyte-mediated lysis by natural HIV-1 altered peptide ligands requires simultaneous presentation of agonist and antagonist peptides. Eur. J. Immunol. 27: 2323-2329.
Price DA, Birtles RJ, Levine TS, Main J, Coker RJ (1997). Bacillary angiomatosis: a role for Phyllobacterium? AIDS 11: 1186-1187.
Goulder PJR, Reid SW, Price DA, McMichael AJ, Phillips RE, Jones EY (1997). Combined structural and immunological refinement of HIV-1 HLA-B8-restricted cytotoxic T lymphocyte epitopes. Eur. J. Immunol. 27: 1515-1521.
Goulder PJR, Sewell AK, Lalloo D, Price DA, Whelan J, Evans J, Taylor G, Luzzi G, Giangrande P, Phillips RE, McMichael AJ (1997). Patterns of immunodominance in HIV-1-specific cytotoxic T lymphocyte responses in two human histocompatibility leukocyte antigen (HLA)-identical siblings with HLA-A*0201 are influenced by epitope mutation. J. Exp. Med. 185: 1423-1433.
Price DA, Klein JL, Fisher M, Main J, Bingham JS, Coker RJ (1997). Potential role for GM-CSF in the treatment of HIV-associated cryptococcal meningitis. AIDS 11: 693-694.
Price DA, Goulder PJR, Klenerman P, Sewell AK, Easterbrook PJ, Troop M, Bangham CRM, Phillips RE (1997). Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection. Proc. Natl. Acad. Sci. USA 94: 1890-1895.
Paige DG, Price DA, Crook T, Main J, Fry L, Weber JN (1996). Isolated cutaneous non-tuberculous mycobacterial infection as a manifestation of AIDS. Clin. Exp. Dermatol. 21: 226-229.
Klein JL, Price DA, Fisher M, Coker RJ (1996). Cytomegalovirus infection: a possible cause of recurrent transient neurological dysfunction in advanced HIV infection. AIDS 10: 345-346.
Price DA, Roberts CM, Rudd RM (1996). Squamous cell carcinoma of the lung and non-metastatic myelopathy. Respir. Dis. Prac. 13: 14-17.
Teare JP, Price DA, Foster GR, McBride M, Goldin RD, Main J (1995). Reversible AIDS-related sclerosing cholangitis. J. Hepatol. 23: 209-211.
Fisher M, Price DA, Klein JL, Weston R, Coker RJ (1995). Cryptococcal disease in HIV infection: treatment and maintenance. AIDS 9: 300-301.
Price DA, Hollings NP, Janes SM, Main J, Coker RJ (1994). Clinical response to the addition of clarithromycin in Pneumocystis carinii pneumonia refractory to high dose co-trimoxazole. J. Antimicrob. Chemother. 34: 303.