Dr John Miles - Publications

Journal Publications

1. Burrows, S.R., Elkington, R.A., Miles, J.J., Green, K.J., Walker, S., Haryana, S.M., Moss, D.J., Dunckley, H., Burrows, J.M. and Khanna R. 2003. Promiscuous CTL recognition of viral epitopes on multiple human leukocyte antigens: biological validation of the proposed HLA A24 supertype. J. Immunol. 171: 1407-1412

2. Miles, J.J.,* Green, K.J.,* Tellam, J., van Zuylen, W.J.M.,Connolly, G. and Burrows, S.R. 2004. Potent T cell response to a class-I-binding 13-mer viral epitope and the influence of HLA micropolymorphism in controlling epitope length. Eur. J. Immunol. 34(9): 2510-2519

3. Tellam, J., Connolly, G., Green, K.J., Miles, J.J., Moss, D.J., Khanna, R. and Burrows, S.R. 2004. Endogenous presentation of CD8+ T cell epitopes from Epstein-Barr virus encoded nuclear antigen 1. J. Exp. Med. 199: 1421-1431

(This article was featured on the cover and was the subject of a commentary in Nat Immunol 2004 6(7):693 and J. Exp. Med.: C. Munz, Epstein-Barr virus nuclear antigen 1: from immunologically invisible to a promising T cell target. J. Exp. Med. 2004. 199: 1301-1304

4. Lew A.E., Bock R.E., Miles J.J., Cuttell. L.B., Steer. P., and Nadin-Davis. S.A. 2004. Sensitive and specific detection of bovine immunodeficiency virus and bovine syncytial virus by 5' Taq nuclease assays with fluorescent 3' minor groove binder-DNA probes. J Virol Methods. 1;116(1): 1-9

5. Borg N.A., Ely L.K., Beddoe T., Macdonald W.A., Reid H.H., Clements C.S., Purcell A.W., Kjer-Nielsen L., Miles J.J., Burrows S.R., McCluskey J., and Rossjohn J. 2005 The CDR3 regions of an immunodominant T cell receptor dictate the 'energetic landscape' of peptide-MHC recognition. Nat. Immunol. 6(2): 171-180

(This article was the subject of a commentary in Nature Immunology 2005 6(2): 130-132)

6. Ely, L.K., Green, K.J., Beddoe, T., Clements, C.S., Miles, J.J., Bottomley, S.P., Kjer-Nielsen, L., Purcell, A.W., McCluskey, J., Rossjohn, J. and Burrows, S.R. 2005. Antagonism of antiviral and allogeneic activity of a human public CTL clonotype by a single altered peptide ligand: implications for allograft rejection. J. Immunol. 174(9): 5593-5601

7. Tynan, F.E., Borg, N.A., Miles, J.J., Beddoe, T., Elhassen, D., Silins, S.L., van Zuylen, W.J.M., Purcell, A.W., Kjer-Nielsen, L., McCluskey, J., Burrows, S.R., and Rossjohn, J. 2005. T cell receptor immunodominance directed towards a highly bulged viral epitope. J Biol Chem. 280(25): 23900-23909

(This article was featured on the cover of J Biol Chem, issue 280[25])

8. Miles, J.J.,* Borg, N.A.,* Elhassen, D., Silins, S.L., Tynan, F.E., Burrows, J.M., Purcell, A.W., Kjer-Nielsen, L., Rossjohn, J., Burrows, S.R., and McCluskey, J. 2005. CTL Recognition of a Bulged Viral Peptide Involves Biased TCR Selection. J. Immunol. 175(6): 3826-3834

9. Tynan, F.E., Burrows, S.R., Bucle. A.M., Clements, C.S., Borg, N.A., Miles, J.J., Beddoe, T., Whisstock, J.C., Wilce, M.C., Silins, S.L., Burrows, J.M., Kjer-Nielsen, L., Kostenko, L., Purcell, A.W., Rossjohn, J., and McCluskey, J. 2005. T cell receptor recognition of a super-bulged MHC-class I bound peptide. Nat. Immunol. 6: 1114-1122

10. Tynan, F.E., Elhassen, D., Burrows. J.M., Miles, J.J., Borg, N.A., Green, K.J., Tellam. J., Purcell, A.W., Kjer-Nielsen, L., McCluskey. J., Rossjohn, J., and Burrows, S.R. 2005. The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformation. J. Exp. Med. 202(9): 1249-1260

11. Miles, J.J., Silins S.L., Brooks A.G., Davis J.E., Misko, I., and Burrows S.R. 2005. T cell grit: large clonal expansions of virus-specific CD8+ T cells can dominate in the peripheral circulation for at least 18 years. Blood. 106(13): 4412-4413

12. Miles, J.J.,* Borg, N.A.,* Brennan, R.M., Tynan, F.E., Kjer-Nielsen, L., Silins, S.L., Bell, M.J., Burrows, J.M., McCluskey, J., Rossjohn, J., and Burrows, S.R., 2006. The role of T cell receptor alpha genes in directing human MHC restriction. J. Immunol. 15; 177(10): 6804-6814

13. Miles, J.J., Silins S.L., and Burrows S.R. 2006. Engineered T cell receptors and their potential in molecular medicine. Current. Med. Chem. 13(23): 2725-2736

14. Archbold J.K., Macdonald W.A., Miles J.J., Brennan R.M., Kjer-Nielsen L., McCluskey J., Burrows S.R., Rossjohn J. 2006. Alloreactivity between disparate cognate and allogeneic pMHC-I complexes is the result of highly focused, peptide-dependent structural mimicry. J Biol Chem. 10;281(45): 34324-34332

15. Tynan F.E., Reid H.H., Kjer-Nielsen L., Miles J.J., Wilce M.C., Kostenko L., Borg N.A., Williamson N.A., Beddoe T., Purcell A.W., Burrows S.R., McCluskey J., Rossjohn J. 2007. A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule. Nat Immunol. 8(3): 268-276

16. Burrows, J.M., Wynn, K.K., Tynan, F.E., Archbold, J., Miles, J.J., Bell, M.J., Brennan, R.M., Walker, S., McCluskey, J., Rossjohn, J., Khanna, R., and Burrows, S.R. 2007. The impact of HLA micropolymorphism outside primary peptide anchor pockets on the CTL response to CMV. Eur. J. Immunol. 37(4): 946-953

17. Miles, J.J.,* Brennan, R.M.,* Silins S.L., Burrows, J.M., Bell, M.J., Burrows, J.M., and Burrows, S.R. 2007. Predictable a� T-Cell Receptor Selection towards a HLA-B*3501-resticted pp65-derived HCMV antigen. J Virol. 81(13): 7269-7273

18. Burrows, J.M., Bell, M.J., Brennan, R.M., Miles, J.J., Khanna, R., and Burrows, S.R. 2008. Preferential binding of unusually long peptides to MHC class I and its influence on the selection of target peptides for T cell recognition. Mol Immunol. 45(6): 1818-24

19. Miles, J.J.,* Elliott, S.L., Suhrbier, A., Lawrence, G., Pye, S.J., Le, T, T., Rosenstengel, A., Nguyen, T, Allworth, A., Burrows, S.R., Cox, J., Pye, D., Moss, D.J., Bharadwaj, M. 2008. A Phase I trial of a CD8+ T Cell Peptide Epitope-based Vaccine for Infectious Mononucleosis. J Virol. 82(3): 1448-57

20. Wynn, K.K., Fulton, Z., Cooper, L., Silins, S.L., Gras, S., Archbold, J.K., Tynan, F.E., Miles, J.J., McCluskey, J., Burrows, S.R., Rossjohn, J., Khanna, R. 2008 Impact of clonal competition for peptide-MHC complexes on the CD8+ T-cell repertoire selection in a persistent viral infection. Blood. 111(8): 4283-4292

21. Bell, M.J., Brennan, R.M., Miles, J.J., Burrows, J.M., Moss, D.J., and Burrows, S.R. 2008. Widespread Sequence Variation in Epstein-Barr Nuclear Antigen 1 Influences the Antiviral T cell Response. J Infect Dis. 197(11): 1594-1597

22. Archbold, J.K., Macdonald, W.A., Gras, S., Theodossis, A., Ely, L.K., Miles, J.J., Bell, M.J., Brennan, R.M., Beddoe, T., Reid, H.H., Wilce, M.C.J., Clements, C.S., Purcell, A.W., McCluskey J., Burrows S.R., and Rossjohn J. Natural micropolymorphism in human leukocyte antigens provides a basis for genetic control of antigen recognition. J. Exp. Med. 206(1): 209-219 2009)

23. Miles, J.J., Brennan, R.M., and Burrows, S.R. 2009. T cell receptor bias in humans. Current Immunology Reviews. 5(1): 10-21

24. Bell, M.J., Burrows, J.M., Brennan, R.M., Miles, J.J., Tellam. J., McCluskey J., Rossjohn J., Khanna, R., and Burrows, S.R. 2009. The peptide length specificity of some HLA class I alleles is very broad and includes peptides of up to 25 amino acids in length. Mol Immunol. (Feb 2009, ahead of print).

25. Yuan, F., Cole, D.K., Rizkallah, P.J., Miles, J.J., Gostick, E., Price, D.A., Gao, G.F., Jakobsen, B.K., and Sewell, A.K., A structural and biophysical basis for cancer recognition by an immunodominant human T cell receptor. J Biol Chem. (In review, April 2009)