Dr Kristin Ladell - Publications

van Bockel DJ, Price DA, Munier ML, Venturi V, Asher TE, Ladell K, Greenaway HY, Zaunders J, Douek DC, Cooper DA, Davenport MP, Kelleher AD. Persistent Survival of Prevalent Clonotypes within an Immunodominant HIV Gag-Specific CD8+ T Cell Response. J Immunol. [Epub ahead of print Dec 6, 2010]

Jones M, Ladell K, Wynn KK, Stacey MA, Quigley MF, Gostick E, Price DA, Humphreys IR (2010) IL-10 restricts memory T cell inflation during cytomegalovirus infection. J Immunol. 2010 Sep 15;185(6):3583-92. [Epub ahead of print Aug 16, 2010]

Harris LD, Klatt NR, Vinton C, Briant JA, Tabb B, Ladell K, Lifson J, Estes JD, Price DA, Hirsch VM, Brenchley JM (2010) Mechanisms underlying {gamma}{delta} T cell subset perturbations in SIV-infected Asian rhesus macaques. Blood [Epub ahead of print Jul 20, 2010]

Subramanya S, Armant M, Salkowitz JR, Nyakeriga AM, Haridas V, Hasan M, Bansal A, Goepfert PA, Wynn KK, Ladell K, Price DA, N M, Kan-Mitchell J, Shankar P (2010) Enhanced Induction of HIV-specific Cytotoxic T Lymphocytes by Dendritic Cell-targeted Delivery of SOCS-1 siRNA. Mol Ther. 18(11):2028-37 [Epub ahead of print Jul 20, 2010]

Cole DK*, Edwards ES*, Wynn KK*, Clement M, Miles JJ, Ladell K, Ekeruche J, Gostick E, Adams KJ, Skowera A, Peakman M, Wooldridge L, Price DA*, Sewell AK* (2010) Modification of MHC Anchor Residues Generates Heteroclitic Peptides That Alter TCR Binding and T Cell Recognition. * equal contribution. J Immunol 185(4):2600-10. [Epub ahead of print Jul 16, 2010]

Van Tendeloo VF*, Van de Velde A*, Van Driessche* A, Cools N*, Anguille S, Ladell K, Gostick E, Vermeulen K, Pieters K, Nijs G, Stein B, Smits EL, Schroyens WA, Gadisseur AP, Vrelust I, Jorens PG, Goossens H, de Vries IJ, Price DA, Oji Y, Oka Y, Sugiyama H, Berneman ZN (2010) Induction of complete and molecular remissions in acute myeloid leukemia by Wilms’ tumor 1 antigen-targeted dendritic cell vaccination. * equal contribution. PNAS USA 107(31):13824-9 [Epub ahead of print Jul 14, 2010]

Wooldridge L*, Clement M*, Lissina A, Edwards ESJ, Ladell K, Ekeruche J, Hewitt RE, Laugel B, Gostick E, Cole DK, Debets R, Berrevoets C, Miles JJ, Burrows SR, Price DA, Sewell AK (2010) MHC class I molecules with superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs. * equal contribution. J Immunol 184(7):3357-66 [Epub ahead of print Feb 26, 2010]

Melenhorst JJ, Scheinberg P, Chattopadhyay PK, Gostick E, Ladell K, Roederer M, Hensel NF, Douek DC, Barrett AJ, Price DA (2009) High avidity myeloid leukemia-associated antigen-specific CD8+ T cells preferentially reside in the bone marrow. Blood 113(10):2238-44 [Epub ahead of print Nov 7, 2008]

Lissina A, Ladell K, Skowera A, Clement M, Edwards E, Seggewiss R, van den Berg HA, Gostick E, Gallagher K, Jones E, Godkin AJ, Peakman M, Price DA, Sewell AK*, Wooldridge L* (2009) Protein kinase inhibitors substantially improve the physical detection of T-cells with peptide-MHC multimers. * equal contribution. J Immunol Methods 340(1):11-24 [Epub ahead of print Oct 16, 2008]

Venturi V, Chin HY, Asher TE, Ladell K, Scheinberg P, Bornstein E, van Bockel D, Kelleher AD, Douek DC, Price DA, Davenport MP (2008) TCR b-chain sharing in human CD8+ T cell responses to cytomegalovirus and Epstein-Barr virus. J Immunol 181(11):7853-62

Chattopadhyay PK, Melenhorst JJ, Ladell K, Gostick E, Scheinberg P, Barrett AJ, Wooldridge L, Roederer M, Sewell AK, Price DA (2008) Techniques to improve the direct ex vivo detection of low frequency antigen-specific CD8+ T cells with peptide-major histocompatibility complex class I tetramers. Cytometry A 73(11):1001-09 [Epub ahead of print Oct 3, 2008]

Ladell K, Hellerstein MK, Cesar D, Busch R, Boban D, McCune JM (2008) Central memory CD8+ T cells appear to have a shorter lifespan and reduced abundance as a function of HIV disease progression. J Immunol 180(12):7907-18

Ladell K*, Dorner M*, Zauner L, Berger C, Zucol F, Bernasconi M, Niggli FK, Speck RF, Nadal D (2007) Immune activation suppresses initiation of lytic Epstein-Barr virus infection. * equal contribution. Cell Microbiol 9: 2055-69 [Epub ahead of print Apr. 5, 2007]

Giger B, Bonanomi A, Odermatt B, Ladell K, Speck RF, Kojic D, Berger C, Niggli FK, Nadal D (2004) Human tonsillar tissue block cultures differ from autologous tonsillar cell suspension cultures in lymphocyte subset activation and cytokine gene expression. J Immunol Methods 289: 179-90

Keyser J, Schultz J, Ladell K, Elzaouk L, Heinzerling L, Pavlovic J, Moelling K (2004) IP-10-encoding plasmid DNA therapy exhibits anti-tumor and anti-metastatic efficiency. Exp Dermatol 13: 380-90

Ladell K, Heinrich J, Schweneker M, Moelling K (2003) A combination of plasmid DNAs encoding murine Flk-1 extracellular domain, murine IL-12 and murine IP-10 lead to tumor regression and survival in melanoma-bearing mice. J Mol Med 81: 271-8