29. Laugel, B., D.K. Cole, M. Clement, L. Wooldridge, D.A. Price, and A. Sewell, K. 2011. The multiple roles of the CD8 coreceptor in T cell biology: oppurtunities for the selective modulation of self-reactive cytotoxic T cells. J Leukoc Biol. In Press. IF: 4.4.
28. Iglesias, M.C., J.R. Almeida, S. Fastenackels, D.J. van Bockel, M. Hashimoto, V. Venturi, E. Gostick, A. Urrutia, L. Wooldridge, M. Clement, S. Gras, P.G. Wilmann, B. Autran, A. Moris, J. Rossjohn, M.P. Davenport, M. Takiguchi, C. Brander, D.C. Douek, A.D. Kelleher, D.A. Price, and V. Appay. 2011. Escape from highly effective public CD8+ T-cell clonotypes by HIV. Blood 118:2138-2149. IF: 10.558.
27. Clement, M., K. Ladell, J. Ekeruche-Makinde, J.J. Miles, E.S. Edwards, G. Dolton, T. Williams, A.J. Schauenburg, D.K. Cole, S.N. Lauder, A.M. Gallimore, A.J. Godkin, S.R. Burrows, D.A. Price, A.K. Sewell, and L. Wooldridge. 2011. Anti-CD8 antibodies can trigger CD8 T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining. J Immunol 187:654-663. IF: 5.745.
26. Miles, J.J., A.M. Bulek, D.K. Cole, E. Gostick, A.J. Schauenburg, G. Dolton, V. Venturi, M.P. Davenport, M.P. Tan, S.R. Burrows, L. Wooldridge, D.A. Price, P.J. Rizkallah, and A.K. Sewell. 2010. Genetic and structural basis for selection of a ubiquitous T cell receptor deployed in Epstein-Barr virus infection. PLoS Pathog 6:e1001198. IF: 9.079.
25. Wooldridge, L., B. Laugel, J. Ekeruche, M. Clement, H.A. van den Berg, D.A. Price, and A.K. Sewell. 2010. CD8 controls T cell cross-reactivity. J Immunol 185:4625-4632. IF: 5.745.
24. Cole, D.K., E.S. Edwards, K.K. Wynn, M. Clement, J.J. Miles, K. Ladell, J. Ekeruche, E. Gostick, K.J. Adams, A. Skowera, M. Peakman, L. Wooldridge, D.A. Price, and A.K. Sewell. 2010. Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition. J Immunol 185:2600-2610. IF: 5.745.
23. Chen, J. L., A. J. Morgan, G. Stewart-Jones, D. Shepherd, G. Bossi, L. Wooldridge, S. L. Hutchinson, A. K. Sewell, G. M. Griffiths, P. A. van der Merwe, E. Y. Jones, A. Galione, and V. Cerundolo. 2010. Ca2+ release from the endoplasmic reticulum of NY-ESO-1-specific T cells is modulated by the affinity of TCR and by the use of the CD8 coreceptor. J Immunol 184:1829-1839. IF: 5.745.
22. Wooldridge, L., M. Clement, A. Lissina, E. S. Edwards, K. Ladell, J. Ekeruche, R. E. Hewitt, B. Laugel, E. Gostick, D. K. Cole, R. Debets, C. Berrevoets, J. J. Miles, S. R. Burrows, D. A. Price, and A. K. Sewell. 2010. MHC class I molecules with Superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs. J Immunol 184:3357-3366. IF: 5.745.
21. Lissina, A., K. Ladell, A. Skowera, M. Clement, E. Edwards, R. Seggewiss, H. A. van den Berg, E. Gostick, K. Gallagher, E. Jones, J. J. Melenhorst, A. J. Godkin, M. Peakman, D. A. Price, A. K. Sewell, and L. Wooldridge. 2009. Protein kinase inhibitors substantially improve the physical detection of T-cells with peptide-MHC tetramers. Journal of immunological methods 340:11-24. IF: 2.340.
20. Wooldridge, L., A. Lissina, D. K. Cole, H. A. van den Berg, D. A. Price, and A. K. Sewell. 2009. Tricks with tetramers: how to get the most from multimeric peptide-MHC. Immunology 126:147-64. IF: 3.302.
19. Skowera, A., J. J. Miles, L. Wooldridge, D. K. Cole, A. Zaremba, R. J. Ellis, A. K. Sewell, and M. Peakman. 2009. Identifying heteroclitic peptides that mimic the major CTL target on preproinsulin in Type I diabetes. Clinical Immunology 131:S88-S88. IF: 3.932.
18. Horlock, C., B. Stott, J. Dyson, G. Ogg, T. McPherson, L. Jones, A. K. Sewell, L. Wooldridge, D. K. Cole, J. Stebbing, and P. Savage. 2009. ELISPOT and functional T cell analyses using HLA mono-specific target cells. J Immunol Methods 350:150-160. IF: 5.745.
17. Weichsel, R., C. Dix, L. Wooldridge, M. Clement, A. Fenton-May, A. K. Sewell, J. Zezula, E. Greiner, E. Gostick, D. A. Price, H. Einsele, and R. Seggewiss. 2008. Profound inhibition of antigen-specific T-cell effector functions by dasatinib. Clin Cancer Res 14:2484-2491. IF: 7.338.
16. Chattopadhyay, P. K., J. J. Melenhorst, K. Ladell, E. Gostick, P. Scheinberg, A. J. Barrett, L. Wooldridge, M. Roederer, A. K. Sewell, and D. A. Price. 2008. Techniques to improve the direct ex vivo detection of low frequency antigen-specific CD8+ T cells with peptide-major histocompatibility complex class I tetramers. Cytometry A 73:1001-1009. IF: 3.749.
15. Melenhorst, J. J., P. Scheinberg, P. K. Chattopadhyay, A. Lissina, E. Gostick, D. K. Cole, L. Wooldridge, H. A. van den Berg, E. Bornstein, N. F. Hensel, D. C. Douek, M. Roederer, A. K. Sewell, A. J. Barrett, and D. A. Price. 2008. Detection of low avidity CD8(+) T cell populations with coreceptor-enhanced peptide-major histocompatibility complex class I tetramers. Journal of immunological methods 338:31-39. IF: 5.745.
14. Wooldridge, L., A. Lissina, J. Vernazza, E. Gostick, B. Laugel, S. L. Hutchinson, F. Mirza, P. R. Dunbar, J. M. Boulter, M. Glick, V. Cerundolo, H. A. van den Berg, D. A. Price, and A. K. Sewell. 2007. Enhanced immunogenicity of CTL antigens through mutation of the CD8 binding MHC class I invariant region. Eur J Immunol 37:1323-1333. IF: 4.942.
13. van den Berg, H. A., L. Wooldridge, B. Laugel, and A. K. Sewell. 2007. Coreceptor CD8-driven modulation of T cell antigen receptor specificity. J Theor Biol 249:395-408. IF: 2.371.
12. Laugel, B., H. A. van den Berg, E. Gostick, D. K. Cole, L. Wooldridge, J. Boulter, A. Milicic, D. A. Price, and A. K. Sewell. 2007. Different T cell receptor affinity thresholds and CD8 coreceptor dependence govern cytotoxic T lymphocyte activation and tetramer binding properties. J Biol Chem 282:23799-23810. IF: 5.328.
11. Gostick, E., D. K. Cole, S. L. Hutchinson, L. Wooldridge, S. Tafuro, B. Laugel, A. Lissina, A. Oxenius, J. M. Boulter, D. A. Price, and A. K. Sewell. 2007. Functional and biophysical characterization of an HLA-A*6801-restricted HIV-specific T cell receptor. Eur J Immunol 37:479-486. IF: 4.942.
10. Wooldridge, L., T. J. Scriba, A. Milicic, B. Laugel, E. Gostick, D. A. Price, R. E. Phillips, and A. K. Sewell. 2006. Anti-coreceptor antibodies profoundly affect staining with peptide-MHC class I and class II tetramers. Eur J Immunol 36:1847-1855. IF: 4.942.
9. Price, D. A., J. M. Brenchley, L. E. Ruff, M. R. Betts, B. J. Hill, M. Roederer, R. A. Koup, S. A. Migueles, E. Gostick, L. Wooldridge, A. K. Sewell, M. Connors, and D. C. Douek. 2005. Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA viruses. J Exp Med 202:1349-1361. IF: 14.5.
8. Wooldridge, L., H. A. van den Berg, M. Glick, E. Gostick, B. Laugel, S. L. Hutchinson, A. Milicic, J. M. Brenchley, D. C. Douek, D. A. Price, and A. K. Sewell. 2005. Interaction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surface. J Biol Chem 280:27491-27501. IF: 5.328.
7. Chen, J. L., G. Stewart-Jones, G. Bossi, N. M. Lissin, L. Wooldridge, E. M. Choi, G. Held, P. R. Dunbar, R. M. Esnouf, M. Sami, J. M. Boulter, P. Rizkallah, C. Renner, A. Sewell, P. A. van der Merwe, B. K. Jakobsen, G. Griffiths, E. Y. Jones, and V. Cerundolo. 2005. Structural and kinetic basis for heightened immunogenicity of T cell vaccines. J Exp Med 201:1243-1255. IF: 14.5.
6. Man-Lik Choi, E., J. L. Chen, L. Wooldridge, M. Salio, A. Lissina, N. Lissin, I. F. Hermans, J. D. Silk, F. Mirza, M. J. Palmowski, P. R. Dunbar, B. K. Jakobsen, A. K. Sewell, and V. Cerundolo. 2003. High avidity antigen-specific CTL identified by CD8-independent tetramer staining. J Immunol 171:5116-5123. IF 5.745.
5. Wooldridge, L., S. L. Hutchinson, E. M. Choi, A. Lissina, E. Jones, F. Mirza, P. R. Dunbar, D. A. Price, V. Cerundolo, and A. K. Sewell. 2003. Anti-CD8 antibodies can inhibit or enhance peptide-MHC class I (pMHCI) multimer binding: this is paralleled by their effects on CTL activation and occurs in the absence of an interaction between pMHCI and CD8 on the cell surface. J Immunol 171:6650-6660. IF: 5.745.
4. Wooldridge, L., S. L. Hutchinson, S. Tafuro, B. Laugel, M. Glick, J. M. Boulter, B. K. Jakobsen, D. A. Price, and A. K. Sewell. 2003. The CD8 T cell coreceptor exhibits disproportionate biological activity at extremely low binding affinities. J Biol Chem 278:24285-24293. IF: 5.328.
3. Wooldridge, L. 2003. Framework for veterinary education and training. Vet Rec 152:375. IF:1.482.
2. Wooldridge, L., Price, D., Man-Lik Choi, E., Mirza, F., Dunbar, P.R., Cerundolo, V. and Sewell, A.K. 2003 CD8 null pMHCI tetramers enable an assessment of CTL quality. Immunology 110:S120. IF: 3.302.
1. Wooldridge, L., and Sewell, A. K. 2002. HIV strategically targets HIV specific T cells. Trends in Immunology 23:474. IF 9.533.