News
Partnership with Immunocore Ltd.
A partnership between a world-leading research group at Cardiff University and an Oxford-based biotechnology company will refine new drugs to treat cancer, HIV and autoimmune disease.
Professor Sewell speaks at Juvenile Diabetes Research Foundation meeting
The University’s latest research into Type 1 diabetes will be outlined by a Cardiff scientist as part of a local conference.
Professor Andy Sewell of the School of Medicine will speak at the Juvenile Diabetes Research Foundation and Diabetes UK Cymru Open Meeting on 21 November 2009.
£3m BBSRC Award
Research into immunity and infection at Cardiff University has been given a multi-million pound boost with a major award from the Biotechnology and Biological Sciences Research Council (BBSRC).
Professor Price wins award
Pioneering research at Cardiff University has been recognised by one of the oldest medical institutions in the world.
The Royal College of Physicians has presented awards to the University’s new President, Professor Sir Martin Evans, FRS and Professor David Price, School of Medicine.
Seeing how we see cancer
A molecular image revealing the interaction between skin cancer cells and T-cells – the cells which protect our body against disease - has been produced by the School of Medicine.
NEW - Molecular structure of the best-studied human cancer T cell antigen revealed
We have used X-ray crystallography to determine the structure of the best ever studied human cancer antigen in complex with a human T-cell receptor. This 'antigen' molecule is upregulated on the surface of human melanoma cells and enables killer T-cells to identify and eliminate these cancerous cells using their T-cell receptor. We anticipate wide interest in this structure as it is only the second human cancer/T-cell receptor complex ever solved. Our T-cells are really designed to eliminate 'foreign molecules' and they are crucial for the elimination of pathogens. T-cells perform less well at eliminating cancer as cancer cells are derived from our own tissue and pose the immune system a greater challenge. A link to the paper, published online at The Journal of Biological Chemistry can be found below:
Cole DK, Yuan F, Rizkallah PJ, Miles JJ, Gostick E, Price DA, Gao GF, Jakobsen BK, Sewell AK.
Germline-governed recognition of a cancer epitope by an immunodominant human T-cell receptor.
Journal of Biological Chemistry. 2009 July. Ahead of Print.
Visualising cancer interactions
A molecular image revealing the interaction between skin cancer cells and T-cells – the cells which protect our body against disease - has been produced by the School of Medicine.
An Immunologists 10 commandments (Immunology News)
Click to download this new article
Advances HIV
Download the Spring 2009 edition of Advances - The Journals for Science, Engineering and Technology in Wales
TOP STORY - Bionic T-cells kill HIV
We have recently published a groundbreaking study in Nature Medicine that utilises engineered T-cells which can target and kill all natural escape variants of HIV in vitro. This discovery has attracted worldwide interests and has been covered by a number of mainstream publications and news broadcasters!! Links can be found below:
