Selected Publications

High Impact Papers 2015

Skowera A, Ladell K, McLaren JE, Dolton G, Matthews KK, Gostick E, Kronenberg-Versteeg D, Eichmann M, Knight RR, Heck S, Powrie J, Bingley PJ, Dayan CM, Miles JJ, Sewell AK, Price DA, Peakman M. β-Cell-Specific CD8 T Cell Phenotype in Type 1 Diabetes Reflects Chronic Autoantigen Exposure. Diabetes. 2015 Mar;64(3):916-25. doi: 10.2337/db14-0332. Epub 2014 Sep 23.

Impact Factor: 8.3.

High Impact Papers 2014

Stepanek O, Prabhakar AS, Osswald C, King CG, Bulek A, Naeher D, Beaufils-Hugo M, Abanto M, Galati V, Hausmann B, Lang R, Cole DK, Huseb E, Sewell AK, Chakraborty AK, and Palmer E. Coreceptor-mediated Lck delivery to the TCR sets the antigen dwell-time threshold for central tolerance. Cell. 2014 Oct 9;159(2):333-45. doi: 10.1016/j.cell.2014.08.042. Epub 2014 Oct 2.

Impact Factor: 33.1.

High Impact Papers 2013

Ekeruche-Makinde J, Miles JJ, van den Berg HA, Skowera A, Cole DK, Dolton G, Schauenburg AJA, Tan MP, Pentier JM, Llewellyn-Lacey S, Miles KM, Bulek AM, Clement M, Williams T, Trimby A, Bailey M, Rizkallah P, Rossjohn J, Peakman M, Price DA, Burrows SR, Sewell AK and Wooldridge L. Peptide length determines the outcome of T cell receptor/peptide-MHCI engagement. Blood. 2012. Feb 14;121(7):1112-23. doi: 10.1182/blood-2012-06-437202. Epub 2012 Dec 18.

Impact Factor: 9.9.

High Impact Papers 2012

Cole DK, Gallagher K, Lemercier B, Holland CJ, Junaid S, HindleyJP, Wynn KW, Gostick E, Sewell AK, Gallimore A, Ladell K, Price DA, Gougeon M and Godkin A. Modification of the C-terminal flanking-region of a universal influenza epitope alters CD4+ T-cell repertoire selection. Nature Communications. 2012 Feb 7;3:665.

Impact Factor: 10.4.

Sewell AK. Why must T cells be cross-reactive? Nat Rev Immunol. 2012 Sep;12(9):669-77. doi: 10.1038/nri3279.

Impact Factor: 33.8.

Knight RR, Kronenberg D, Zhao M, Huang GC, Bulek A, Wooldridge L, Cole DK, Sewell AK, Peakman M, Skowera A. Human β-cell killing by autoreactive preproinsulin-specific CD8 T cells is predominantly granule-mediated with the potency dependent upon TCR avidity. Diabetes. 2012 Aug 30, Diabetes doi:10.2337/db 12-0315.

(Impact Factor 8.3)

Liddy N, Bossi G, Adams KJ, Lissina A, Mahon TM, Hassan NJ, Gavarret J, Bianchi FC, Pumphrey NJ, Ladell K, Gostick E, Sewell AK, Lissin NM, Harwood NE, Molloy PE, Li Y, Cameron BJ, Sami M, Baston EE, Todorov PT, Paston SJ, Dennis RE, Harper JV, Dunn SM, Ashfield R, Johnson A, McGrath Y, Plesa G, June CH, Kalos M, Price DA, Vuidepot A, Williams DD, Sutton DH, Jakobsen BK. Monoclonal TCR-redirected tumor cell killing. Nature Medicine. 2012 Jun 18;6980-987.

(Impact Factor 25)

Bulek AM*, Cole DK*, Skowera S*, Dolton G, Gras S, Madura F, Fuller A, Miles JJ, Gostick E, Price DA, Drijfhout JW, Knight RR, Huang GC, Lissin N, Molloy PE, Wooldridge L, Jakobsen BK, Rossjohn J, Peakman M*, Rizkallah PJ* and Sewell AK* (*equal contribution). Structural basis of human β-cell killing by CD8+ T cells in Type 1 diabetes. Nature Immunology. 2012 Jan 15;13(3):283-9. *News and views in Nature Immunology and *voted in the top 2% of all biomedical publications in FS1000.

(Impact Factor 25.7)

High Impact Papers 2011

Agnew C, Borodina E, Zaccai NR, Conners R, Burton NM, Vicary JA, Cole DK, Antognozzi M, Virji M, Brady RL. Correlation of in situ mechanosensitive responses of the Moraxella catarrhalis adhesin UspA1 with fibronectin and receptor CEACAM1 binding. Proceedings of the National Acadamy of Science U S A. 2011 Sep 13;108(37):15174-8. Epub 2011 Aug 29.

(Impact Factor 9.8)

Vivian JP, Duncan RC, Berry R, O'Connor GM, Reid HH, Beddoe T, Gras S, Saunders PM, Olshina MA, Widjaja JML, Harpur CM, Lin J, Maloveste SM, Price DA, Lafont BAP, McVicar DW, Clements CS, Brooks AG, Rossjohn J. Killer cell immunoglobulin-like receptor 3DL1-mediated recognition of human leukocyte antigen B. Nature. 2011 Nov; 479, 7373;401-U155.

(Impact Factor 31)

High Impact Papers 2010

Miles JJ*, Bulek A*, Cole DK*, Gostick E, Schauenburg AJA, Dolton G, Venturi V, Davenport MP, Tan MP, Burrows SR, Wooldridge L, Price DA, Rizkallah PJ* and Sewell AK* (*equal contribution). Genetic and structural basis for selection of a ubiquitous T cell receptor deployed in Epstein-Barr virus infection. PLOS Pathogens. 2010 Nov 18;6(11):e1001198.

(Impact Factor 9.1)

High Impact Papers 2009

Borbulevych O.Y., K.H. Piepenbrink, B.E. Gloor, D.R. Scott, R.F. Sommese D.K. Cole, A.K. Sewell, and B.M. Baker (2009) T cell receptor crossreactivity directed by antigen-dependent tuning of peptide-MHC molecular flexibility. Immunity. 2009 31, 885-96.

(Impact Factor 20.8)

Archbold J.K., W.A. Macdonald, S. Gras S, L.K. Ely, J.J. Miles, M.J. Bell, R.M. Brennan, T. Beddoe, M.C. Wilce, C.S. Clements, A.W. Purcell, J. McCluskey, S.R. Burrows and Rossjohn (2009). Natural micropolymorphism in human leukocyte antigens provides a basis for genetic control of antigen recognition. Journal of Experimental Medicine, 206, 209-19.

(Impact Factor 15.2)

High Impact Papers 2008

Varela-Rohena, A., P.E. Molloy, S. M. Dunn, Y. Li, M. M. Suhoski, R.G. Carroll, A. Milicic, T. Mahon, D.H. Sutton, B.E. Laugel, R. Moysey, B.J. Cameron, A. Vuidepot, M.E. Purbhoo, D.K. Cole, R.E. Phillips, C.H. June, B.K. Jakobsen, J.L. Riley* and A.K. Sewell* (2008) Control of HIV-1 immune escape by CD8 T-cells expressing enhanced T-cell receptor (*equal contribution) Nature Medicine 14, 1390-5.

(Impact Factor 29)

Skowera, A., R.J. Elps, R. Varela-Calvino, S. Arif, G.C. Huang, C. Van-Krinks, A. Zaremba, C. Rackham, J.S. Allen, T.I. Tree, M. Zhao, M. C.M. Dayan, A.K. Sewell, W. Unger, J.W. Drijfhout, F. Ossendorp, B.O. Roep and M. Peakman (2008) CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope. Journal of Clinical Investigation, 118, 3390-3402.

(Impact Factor 17.1)

Kasprowicz, V. S.M. Ward, A. Turner, A. Grammatikos, B. Nolan, L. Lewis-Ximenez, C. Sharp, J. Woodruff, V. Fleming, S. Sims, B.D. Walker, A. Sewell, G M. Lauer and P Klenerman (2008). Defining the directionalty and quality of CD8+ T cell heterologous immunity in hepatitis C virus infection. Journal of Clinical Investigation, 118, 1143-53.

(Impact Factor 17.1)

Jo, J., U Aichelle, N. Kersting, R. Klein, P. Aichele, E. Bisse, A. K Sewell, H.E. Blum, R. Bartenschlager, V. Lohmann and R. Thimme (2009) Analysis of CD8+ T-cell-mediated inhibition of hepatitis C virus replication using a novel immunological model. Gastroenterology, 136, 1391-401.


Wynn K.K., Z. Fulton, L. Cooper, S.L. Silins, S. Gras, J.K. Archbold, E.E. Tynan, J.J. Miles, J. McCluskey, S.R. Burrows, J. Rossjohn, and R. Khanna R (2008). Impact of clonal competition for peptide-MHC complexes on the CD8+ T-cell repertoire selection in a persistent viral infection. Blood, 111, 4283-92.

(Impact Factor 10.8)